Evidence map›Paper›PMID 29209598›Full record

ArticleFrontiers in pediatrics2017

Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Permissive Hypercapnia.

Sarah Gentner, Mandy Laube, Ulrike Uhlig, Yang Yang, Hans W Fuchs, Jens Dreyhaupt, Helmut D Hummler, Stefan Uhlig, Ulrich H Thome

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Article in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah GentnerDivision of Vascular Surgery, University of Ulm, Ulm, Germany.
Mandy LaubeCenter for Pediatric Research Leipzig, Hospital for Children and Adolescents, Division of Neonatology, University of Leipzig, Leipzig, Germany.
Ulrike UhligInstitute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany.
Yang YangInstitute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany.
Hans W FuchsCenter for Pediatrics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jens DreyhauptInstitute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Helmut D HummlerDivision of Neonatology and Pediatric Critical Care, Department of Pediatrics, University of Ulm, Ulm, Germany.
Stefan UhligInstitute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany.
Ulrich H ThomeCenter for Pediatric Research Leipzig, Hospital for Children and Adolescents, Division of Neonatology, University of Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVentilator-induced lung injury is considered to be a main factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Optimizing ventilator strategies may reduce respiratory morbidities in preterm infants. Permissive hypercapnia has been suggested to attenuate lung injury. We aimed to determine if a higher PCO

methodsDuring a multicenter trial of permissive hypercapnia in extremely low birthweight infants (PHELBI), preterm infants (birthweight 400-1,000 g, gestational age 23 0/7-28 6/7 weeks) requiring mechanical ventilation within 24 h of birth were randomly assigned to a high PCO MAIN

findingsLevels of inflammatory cytokines and ASM were similar in both groups: interleukin (IL)-6 (

conclusionThe results suggest that high PCO

trial registrationISRCTN56143743.

Indexed as

bronchopulmonary dysplasiapermissive hypercapniapreterm infantspulmonary inflammationtracheal aspirates

Identifiers

PMID29209598
PMCPMC5702441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.