ArticleChild and adolescent psychiatry and mental health2017
Minor physical anomalies in neurodevelopmental disorders: a twin study.
Article in Child and adolescent psychiatry and mental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders.Scientific reports · 2020Trial
- Article
- Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study.Child psychiatry and human development · 2025Article
- Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder.BMC psychiatry · 2021Article
- Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities.Brain and behavior · 2021Article
- Behavioral and biological divergence in monozygotic twin pairs discordant for autism phenotypes: A systematic review.JCPP advances · 2021Article
- Presynaptic dysfunction in CASK-related neurodevelopmental disorders.Translational psychiatry · 2020Article
- Why Does the Face Predict the Brain? Neural Crest Induction, Craniofacial Morphogenesis, and Neural Circuit Development.Frontiers in physiology · 2020Review
- Variable neurodevelopmental and morphological phenotypes of carriers with 12q12 duplications.Molecular genetics & genomic medicine · 2020Article
- Are There Any Biomarkers for Pedophilia and Sexual Child Abuse? A Review.Frontiers in psychiatry · 2019Review
- Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model.Journal of developmental biology · 2018Review
- 2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study.Journal of autism and developmental disorders · 2018Article
- Prevalence of minor physical anomalies in children with autism spectrum disorder reporting to a tertiary care hospital Lahore-Pakistan.Pakistan journal of medical sciencesArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMinor physical anomalies (MPAs) are subtle anatomical deviations in one's appearance and may suggest altered embryogenesis. MPAs have been shown to be more common in neurodevelopmental disorders (NDDs) compared with typical development. Still, further studies are needed on MPAs in NDDs, especially using twins to adjust for confounding familial factors.
methodsClinical assessments were conducted on 116 twins (61 NDD, 55 controls) from 51 monozygotic and 7 dizygotic pairs to examine MPAs and their association with DSM-5 defined NDDs. Additionally, the relationship between the number of MPAs within twins by zygosity was investigated.
resultsWithin the cohort sample, a specific association was found between MPAs and autism spectrum disorder (ASD) diagnosis (crude odds ratio = 1.29, p = .047; adjusted odds ratios = 1.26-1.33, adjusted p values = .032-.073) and autistic traits (crude β = 3.02, p = .002; adjusted β = 2.28, p = .019), but not NDDs in general or ADHD, nor within-pairs. Identified MPAs in ASD included overweight, hypermobility, pes planus, straight eyebrows, vision impairment, arachnodactyly/long toes, long eyelashes, and microtia. The number of MPAs within all monozygotic pairs was highly correlated (r = .88, p < .001).
conclusionMPAs are more frequent in participants with ASD and may be influenced by genetics. The value of MPAs for (early) detection should be further explored, as they might index individuals at increased risk for ASD in particular.
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