ArticleJournal of occupational medicine and toxicology (London, England)2017
Heavy metals effect on breast cancer progression.
Article in Journal of occupational medicine and toxicology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- The preventive and carcinogenic effect of metals on cancer: a systematic review.BMC public health · 2024Pooled it
- Disruption of Elemental Homeostasis and Oxidative Balance in Breast Cancer Patients: The Role of Heavy Metals and Trace Elements.Biological trace element research · 2026Article
- Association of Per- and Polyfluoroalkyl Substances with Pan-Cancers Associated with Sex Hormones.Toxics · 2025Article
- Levels of Mineral Elements in Different Organs of Dogs from the Ionian-Etnean Volcanic Area.Animals : an open access journal from MDPI · 2025Article
- Mercury Bioaccumulation in Female Breast Cancer Is Associated to CXCR4 Expression.International journal of molecular sciences · 2025Article
- Blood lead levels and bladder cancer among US participants: NHANES 1999-2018.BMC public health · 2025Article
- Quantitative distribution of essential elements and non-essential metals in breast cancer tissues by LA-ICP-TOF-MS.Analytical and bioanalytical chemistry · 2025Article
- Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies.International journal of environmental research and public health · 2024Review
- Time-specific impact of trace metals on breast density of adolescent girls in Santiago, Chile.International journal of cancer · 2024Article
- Domestic dogs as environmental sentinel in comparative toxicologic pathology: Assessment of metals and rare earth elements concentrations in healthy and neoplastic mammary glands.One health (Amsterdam, Netherlands) · 2024Article
- Breast Cancer Exposomics.Life (Basel, Switzerland) · 2024Review
- Exploring the intricate relationship between miRNA dysregulation and breast cancer development: insights into the impact of environmental chemicals.Frontiers in immunology · 2024Review
- Does insulin make breast cancer cells resistant to doxorubicin toxicity?Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Urinary Concentrations of Endocrine-Disrupting Metals and Prevalent Breast Cancer in US Women.Biological trace element research · 2023Article
- A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices.Molecules (Basel, Switzerland) · 2023Article
- National and subnational burden of female and male breast cancer and risk factors in Iran from 1990 to 2019: results from the Global Burden of Disease study 2019.Breast cancer research : BCR · 2023Article
- Genotoxic Biomonitoring in Children Living near the El Fraile Mine Tailings in Northern Guerrero State, Mexico.Toxics · 2022Article
- Ambient air emissions of endocrine-disrupting metals and the incidence of hormone receptor- and HER2-dependent female breast cancer in USA.Medical oncology (Northwood, London, England) · 2022Article
- Association between trace elements in cancerous and non-cancerous tissues with the risk of breast cancers in western Iran.Environmental science and pollution research international · 2022Article
- Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women's Health.International journal of environmental research and public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer is the most frequent localization of malignant process in American women and women of European countries. To date it is not possible to control the morbidity growth due to lack of effective ways of primary prevention. Comparing the incidence of breast cancer in developed countries with the countries of Asia and Africa, there is the fact of population predominance lesion in more urbanized countries. This suggests that the environment along with other factors, occupies a significant place in the initiation and progression of breast neoplasia. The impressive rates of industrial development led to the pollution of soil, surface water and, as a consequence, food by heavy metal salts.The purposes of this paper are as follows: the chemical composition determination of neoplastic breast tissue, evaluation of the DNA methylation level, study of prognostic-important receptors expression in the breast cancer cells, establishing linkages between all the derived indicators.
methodsIn our study we used the following methods: studying of the chemical composition of breast cancer tissue by atomic absorption spectrophotometry and energy-dispersion spectrometer; іmmunohistochemical study of ER, PR, HER2/neu, p53, Ki-67, E-cadherin and MGMT receptors; DNA extraction and investigation by oscillating infrared spectroscopy method.
resultsThe total amount of heavy metals in breast cancer tissue ranged from 51.21 × 10
conclusionsHeavy metals through different pathogenetic links stimulate the progression of breast cancer and reduce its sensitivity to treatment. DNA of tumor tissue has a different level of methylation which changes with the amount of heavy metals in cancer cells. This is displayed on the synthesis of prognostically important receptors in neoplastic tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.