Evidence map›Paper›PMID 29209388›Full record

ArticlePsychiatry investigation2017

A Genome-Wide Association Study Identifies

Chul-Hyun Cho, Ji-Hye Choi, Seung-Gul Kang, Ho-Kyoung Yoon, Young-Min Park, Joung-Ho Moon, Ki-Young Jung, Jin-Kyu Han, Hong-Bum Shin, Hyun Ji Noh and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Psychiatry investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Polygenic risk scores in neurological disorders: restless legs syndrome as a translational model.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Chul-Hyun ChoDepartment of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Ji-Hye ChoiDepartment of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Seung-Gul KangDepartment of Psychiatry, School of Medicine, Gachon University, Incheon, Republic of Korea.
Ho-Kyoung YoonDepartment of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Young-Min ParkDepartment of Psychiatry, Inje University, Ilsan Paik Hospital, Goyang, Republic of Korea.
Joung-Ho MoonDepartment of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Ki-Young JungDepartment of Neurology, Seoul University College of Medicine, Seoul, Republic of Korea.
Jin-Kyu HanSeoul Sleep Center, Seoul, Republic of Korea.
Hong-Bum ShinKosleep Clinic, Seoul, Republic of Korea.
Hyun Ji NohBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yong Seo KooDepartment of Neurology, Korea University College of Medicine, Seoul, Republic of Korea.
Leen KimDepartment of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Hyun Goo WooDepartment of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Heon-Jeong LeeDepartment of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Korea University · KRAjou University · KRBroad Institute · USGachon University · KRInje University Ilsan Paik Hospital · KRSeoul Sleep Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRestless legs syndrome (RLS) is a highly heritable and common neurological sensorimotor disease disturbing sleep. The objective of study was to investigate significant gene for RLS by performing GWA and replication study in a Korean population.

methodsWe performed a GWA study for RLS symptom group (n=325) and non-RLS group (n=2,603) from the Korea Genome Epidemiology Study. We subsequently performed a replication study in RLS and normal controls (227 RLS and 229 controls) to confirm the present GWA study findings as well as previous GWA study results.

resultsIn the initial GWA study of RLS, we observed an association of rs11645604 (OR=1.531, p=1.18×10

conclusionFrom our sequential GWA and replication study, we could hypothesize rs9390170 polymorphism in

Indexed as

Genome-wide association studyReplication studyRestless legs syndromeUTRNUtrophin

Identifiers

PMID29209388
PMCPMC5714726
OpenAlexW2773753641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.