ArticleFrontiers in psychiatry2017
Decreased Left Putamen and Thalamus Volume Correlates with Delusions in First-Episode Schizophrenia Patients.
Article in Frontiers in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRIJournal of psychiatry & neuroscience : JPN · 2020Pooled it
- Effect of meditation on clinical symptoms and gray matter volume in chronic schizophrenia: a randomized controlled trial.European archives of psychiatry and clinical neuroscience · 2026Trial
- Bilateral putamen necrosis in a case of dyskinetic movements and schizophrenia - A case report.Indian journal of psychiatry · 2026Article
- Frontal-striatal-thalamic circuit dysfunction and inferential processing between internal representations and external events across the psychosis spectrum.Frontiers in psychiatry · 2026Review
- Multimodal biological profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2025Article
- The neuroscience of itch in relation to transdiagnostic psychological approaches.Scientific reports · 2024Article
- Differences in fractional amplitude of low-frequency fluctuations (fALFF) and cognitive function between untreated major depressive disorder and schizophrenia with depressive mood patients.BMC psychiatry · 2024Article
- Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2024Article
- Predicting new onset thought disorder in early adolescence with optimized deep learning implicates environmental-putamen interactions.medRxiv : the preprint server for health sciences · 2023Article
- A significant, functional and replicable risk KTN1 variant block for schizophrenia.Scientific reports · 2023Article
- Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Striatum-related spontaneous coactivation patterns predict treatment response on positive symptoms of drug-naive first-episode schizophrenia with risperidone monotherapy.Frontiers in psychiatry · 2023Article
- Identification of texture MRI brain abnormalities on first-episode psychosis and clinical high-risk subjects using explainable artificial intelligence.Translational psychiatry · 2022Article
- Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia.Biological psychiatry · 2022Review
- Multimodal brain deficits shared in early-onset and adult-onset schizophrenia predict positive symptoms regardless of illness stage.Human brain mapping · 2022Article
- Graph Convolutional Networks Reveal Network-Level Functional Dysconnectivity in Schizophrenia.Schizophrenia bulletin · 2022Article
- Cerebellar and basal ganglia motor network predicts trait depression and hyperactivity.Frontiers in behavioral neuroscience · 2022Article
- Psychopathological Syndromes Across Affective and Psychotic Disorders Correlate With Gray Matter Volumes.Schizophrenia bulletin · 2021Article
- Systematic review: the relationship between sleep spindle activity with cognitive functions, positive and negative symptoms in psychosis.Sleep medicine: X · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelusional thinking is one of the hallmark symptoms of schizophrenia. However, the underlying neural substrate for delusions in schizophrenia remains unknown. In an attempt to further our understanding of the neural basis of delusions, we explored gray matter deficits and their clinical associations in first-episode schizophrenia patients with and without delusions.
methodsTwenty-four first-episode schizophrenia patients with delusions and 18 without delusions as well as 26 healthy controls (HC) underwent clinical assessment and whole-brain structural imaging which were acquired a 3.0 T scanner. Voxel-based morphometry was used to explore inter-group differences in gray matter volume using analysis of covariance, and Spearman correlation coefficients (rho) between the Scale for the Assessment of Positive Symptoms (SAPS)-delusion scores and mean regional brain volumes was obtained.
resultsPatients with delusions showed decreased brain gray matter volumes in the left putamen, thalamus, and caudate regions compared with HC. Patients with delusions also showed decreased regional volume in the left putamen and thalamus compared with patients without delusions. SAPS-delusion scores were negatively correlated with the gray matter volumes of the left putamen and thalamus. DISCUSSION: Left putamen and thalamus volume loss may be biological correlates of delusions in schizophrenia.
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