ArticleFrontiers in aging neuroscience2017
Asymmetry of Hemispheric Network Topology Reveals Dissociable Processes between Functional and Structural Brain Connectome in Community-Living Elders.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Relating Cognition to both Brain Structure and Function: A Systematic Review of Methods.Brain connectivity · 2023Pooled it
- Hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks.Annals of medicine · 2026Article
- Functional divergence between the two cerebral hemispheres contributes to human fluid intelligence.Communications biology · 2025Article
- Altered neurovascular coupling and structure-function coupling in Moyamoya disease affect postoperative collateral formation.Scientific reports · 2024Article
- Genetic architecture of the white matter connectome of the human brain.Science advances · 2023Article
- Driving Fatigue Detection with Three Non-Hair-Bearing EEG Channels and Modified Transformer Model.Entropy (Basel, Switzerland) · 2022Article
- Heritability and cross-species comparisons of human cortical functional organization asymmetry.eLife · 2022Article
- Is it left or is it right? A classification approach for investigating hemispheric differences in low and high dimensionality.Brain structure & function · 2022Article
- Subdividing Stress Groups into Eustress and Distress Groups Using Laterality Index Calculated from Brain Hemodynamic Response.Biosensors · 2022Article
- Gender-Related and Hemispheric Effects in Cortical Thickness-Based Hemispheric Brain Morphological Network.BioMed research international · 2020Article
- Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation.Aging · 2019Article
- Multimodal neuroimaging study reveals dissociable processes between structural and functional networks in patients with subacute intracerebral hemorrhage.Medical & biological engineering & computing · 2019Article
- Functional near-infrared spectroscopy evidence for the development of topological asymmetry between hemispheric brain networks from childhood to adulthood.Neurophotonics · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
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Abstract
Human brain is structurally and functionally asymmetrical and the asymmetries of brain phenotypes have been shown to change in normal aging. Recent advances in graph theoretical analysis have showed topological lateralization between hemispheric networks in the human brain throughout the lifespan. Nevertheless, apparent discrepancies of hemispheric asymmetry were reported between the structural and functional brain networks, indicating the potentially complex asymmetry patterns between structural and functional networks in aging population. In this study, using multimodal neuroimaging (resting-state fMRI and structural diffusion tensor imaging), we investigated the characteristics of hemispheric network topology in 76 (male/female = 15/61, age = 70.08 ± 5.30 years) community-dwelling older adults. Hemispheric functional and structural brain networks were obtained for each participant. Graph theoretical approaches were then employed to estimate the hemispheric topological properties. We found that the optimal small-world properties were preserved in both structural and functional hemispheric networks in older adults. Moreover, a leftward asymmetry in both global and local levels were observed in structural brain networks in comparison with a symmetric pattern in functional brain network, suggesting a dissociable process of hemispheric asymmetry between structural and functional connectome in healthy older adults. Finally, the scores of hemispheric asymmetry in both structural and functional networks were associated with behavioral performance in various cognitive domains. Taken together, these findings provide new insights into the lateralized nature of multimodal brain connectivity, highlight the potentially complex relationship between structural and functional brain network alterations, and augment our understanding of asymmetric structural and functional specializations in normal aging.
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