ArticleWorld journal of gastroenterology2017
Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells.
Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Preventive and Ameliorative Effects of Se- and Zn-Biofortified Chickpeas on MAFLD-Related Metabolic Disturbances.Foods (Basel, Switzerland) · 2026Article
- Novel Insights into G0S2 as a Central Regulator of Lipid Metabolism and Its Implications for Meat Quality.Animals : an open access journal from MDPI · 2026Review
- Yongchun Aged Vinegar Powder: Preparation, Characterization, and Effects on Sodium Oleate-Induced Steatosis in HepG2 Cells.Foods (Basel, Switzerland) · 2026Article
- Palmitate-induced downregulation of lipocalin prostaglandin DMolecular and cellular endocrinology · 2025Article
- Recent advances on the role of G0S2.Discover oncology · 2025Review
- Protective effects of betaine on the early fatty liver in laying hens through ameliorating lipid metabolism and oxidative stress.Frontiers in nutrition · 2024Article
- Goat miR-92a-3p TargetsGenes · 2023Article
- The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue.International journal of molecular sciences · 2023Article
- Identification and Validation of Hub Immune-Related Genes in Non-Alcoholic Fatty Liver Disease.International journal of general medicine · 2023Article
- Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism.Clinical and translational medicine · 2022Article
- Fatty acid tryptamide from cacao elongates Drosophila melanogaster lifespan with sirtuin-dependent heat shock protein expression.Scientific reports · 2022Article
- Menin regulates lipid deposition in mouse hepatocytes via interacting with transcription factor FoxO1.Molecular and cellular biochemistry · 2022Article
- Retraction Note: The nuclear orphan receptor Nur77 alleviates palmitate-induced fat accumulation by down-regulating G0S2 in HepG2 cells.Scientific reports · 2022Article
- A mix of chlorogenic and caffeic acid reduces C/EBPß and PPAR-γ1 levels and counteracts lipid accumulation in macrophages.European journal of nutrition · 2022Article
- Recent Advances on the Role of ATGL in Cancer.Frontiers in oncology · 2022Review
- Anti-adipogenic effect of the flavonoids through the activation of AMPK in palmitate (PA)-treated HepG2 cells.Journal of veterinary science · 2022Article
- Quercetin ameliorates chicken quality by activating the PI3K/PKB/AMPK signaling pathway in broilers.Frontiers in veterinary science · 2022Article
- Effect of Quercetin on Lipids Metabolism Through Modulating the Gut Microbial and AMPK/PPAR Signaling Pathway in Broilers.Frontiers in cell and developmental biology · 2021Article
- ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.Theranostics · 2021Article
- Palmitate and Fructose Interact to Induce Human Hepatocytes to Produce Pro-Fibrotic Transcriptional Responses in Hepatic Stellate Cells Exposed to Conditioned Media.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the role of G0/G1 switch gene 2 (G0S2) and its transcriptional regulation in palmitate-induced hepatic lipid accumulation.
methodsHepG2 cells were treated with palmitate, or palmitate in combination with CCAAT/enhancer binding protein (C/EBP)β siRNA or G0S2 siRNA. The mRNA expression of C/EBPβ, peroxisome proliferator-activated receptor (PPAR)γ and PPARγ target genes (
resultsPalmitate caused a dose-dependent increase in lipid accumulation and a dose-dependent decrease in lipolysis in HepG2 cells. In addition, palmitate increased the mRNA expression of C/EBPβ, PPARγ, and PPARγ target genes (
conclusionPalmitate can induce lipid accumulation in HepG2 cells by activating C/EBPβ-mediated G0S2 expression.
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