Evidence map›Paper›PMID 29209088›Full record

ArticleScientific reports2017

Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP

Sandeep Chakraborty, Artashes Karmenyan, Jin-Wu Tsai, Arthur Chiou

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Chemical constituents in the rhizome of Curcuma longa and the pharmacological importance of curcumin hybrids.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sandeep ChakrabortyBiophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, 11221, Taiwan, ROC. sandeep_nanotsk@yahoo.co.in.
Artashes KarmenyanDepartment of Physics, National Dong Hwa University, Hualien, 97401, Taiwan, ROC.
Jin-Wu TsaiInstitute of Brain Science, National Yang-Ming University, Taipei, 11221, Taiwan, ROC.
Arthur ChiouBiophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, 11221, Taiwan, ROC. aechiou@ym.edu.tw.
National Yang Ming Chiao Tung University · TWNational Dong Hwa University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development and progression of neurodegenerative diseases like Parkinson's disease (PD) involve multiple pathways. Thus, effective therapeutic treatments should intervene to address all these pathways simultaneously for greater success. Most of the current pharmacotherapeutic approaches just supplement striatal dopamine. Hence, natural extracts of plants with therapeutic potential have been explored. Curcuminoids belong to one such group of polyphenol which show immense therapeutic effects. Here, we have used intracellular reactive oxygen species (ROS) measurement, and two-photon fluorescence lifetime imaging microscopy (2P-FLIM) of cellular autofluorescent co-enzyme reduced nicotinamide adenine dinucleotide (NADH) to study the inhibitory effects of curcumin and cyclocurcumin in alleviating PD like neurotoxicity of 1-methyl-4-phenylpyridinium (MPP

Indexed as

1-Methyl-4-phenylpyridiniumAnimalsCell DifferentiationCell SurvivalCurcuminMicroscopy, FluorescenceNADNerve Growth FactorNeuroprotective AgentsNeurotoxicity SyndromesParkinson DiseasePC12 CellsRatsReactive Oxygen Species1-Methyl-4-phenylpyridiniumCurcuminNADNerve Growth FactorNeuroprotective AgentsReactive Oxygen Species

Identifiers

PMID29209088
PMCPMC5717177
OpenAlexW2769850976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.