ArticleScientific reports2017
Preoperative serum thyroglobulin predicts initial distant metastasis in patients with differentiated thyroid cancer.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The role of preoperative serum thyroglobulin in the diagnosis and treatment of differentiated thyroid cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Diagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma.Frontiers in immunology · 2025Article
- Development and validation of an interpretable machine learning model for predicting the risk of distant metastasis in papillary thyroid cancer: a multicenter study.EClinicalMedicine · 2024Article
- Graves' orbitopathy development in thyroid cancer patients: a 16-year nationwide cohort study in South Korea.Eye (London, England) · 2024Article
- Management of follicular thyroid carcinoma.European thyroid journal · 2024Review
- The alternative value of thyroid stimulating hormone instead of thyroglobulin in differentiation of follicular thyroid neoplasm in Hashimoto's thyroiditis.Frontiers in oncology · 2024Article
- The Unique Importance of Differentiation and Function in Endocrine Neoplasia.Endocrine pathology · 2023Review
- Thyroglobulin as a Rapid and Cost-Effective Biomarker for Diagnosis of Thyroid Carcinoma Brain Metastasis: A Case Report of a Patient with Metastatic Hurthle Cell Thyroid Carcinoma.The American journal of case reports · 2023Article
- Analysis of factors associated with the prognosis of papillary thyroid cancer and the construction of a survival model.Cancer medicine · 2023Article
- The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer.Frontiers in endocrinology · 2022Review
- Nomogram model based on preoperative serum thyroglobulin and clinical characteristics of papillary thyroid carcinoma to predict cervical lymph node metastasis.Frontiers in endocrinology · 2022Article
- LINC01816 promotes the migration, invasion and epithelial‑mesenchymal transition of thyroid carcinoma cells by sponging miR‑34c‑5p and regulating CRABP2 expression levels.Oncology reports · 2021Article
- Article
- Review
- Preoperative Serum Thyroglobulin and Its Correlation with the Burden and Extent of Differentiated Thyroid Cancer.Cancers · 2020Article
- Preoperative serum thyroglobulin is a risk factor of skip metastasis in papillary thyroid carcinoma.Annals of translational medicine · 2020Article
- The Blood Biomarkers of Thyroid Cancer.Cancer management and research · 2020Review
- Improved survival after early detection of asymptomatic distant metastasis in patients with thyroid cancer.Scientific reports · 2019Article
- Synergic effects of histology subtype, tumor size, and lymph node metastasis on distant metastasis in differentiated thyroid cancer.Annals of translational medicine · 2019Article
- Sacral Metastasis in Follicular Thyroid Carcinoma: Cytology Pitfalls and Serum Thyroglobulin Utility.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differentiated thyroid cancer (DTC) generally has a favorable prognosis. However, a small percentage of patients suffer from initial distant metastasis (DM). To date, there is no effective predictor for the presence of initial DM. The aim of this study was to determine if preoperative serum thyroglobulin (Tg) level could predict initial DM in DTC. We reviewed an institutional thyroid cancer database from October 1994 to February 2016. To determine the Tg cutoff for predicting initial DM, 4,735 patients who were diagnosed with DTC were included in this study. Fifty-seven patients (1.2%) were identified as having DTC with initial DM. Median preoperative Tg level was 328.4 ng/ml in the initial DM group and 10.0 ng/ml in the non-DM group. Initial DM was the most important factor affecting serum Tg level (β = 2,049.32 ± 103.40; P < 0.001). The Tg cutoff level that distinguished overall DM with the greatest accuracy was 63.4 ng/ml [area under the ROC curve 0.914, sensitivity 84.2%, specificity 90.6%, negative likelihood ratio (LR) 0.17, and positive LR 8.97]. Preoperative Tg levels were useful for predicting initial DM of DTC. Measurement of serum Tg in patients with DTC may guide preoperative staging evaluation and initial treatment.
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