Evidence map›Paper›PMID 29209044›Full record

ArticleLeukemia2018

Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.

F Maura, M Petljak, M Lionetti, I Cifola, W Liang, E Pinatel, L B Alexandrov, A Fullam, I Martincorena, K J Dawson and 15 more

Abstract readLetter
In one paragraph

Article in Leukemia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Guideline
  2. Pooled it
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Genomics Define Malignant Transformation in Myeloma Precursor Conditions.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Article
  8. Defining High-Risk Disease Biology in Multiple Myeloma: A Narrative Review.Blood and lymphatic cancer : targets and therapy · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. [Chinese expert consensus on the diagnosis and treatment of plasma cell leukemia (2025)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025
    Article
  14. Article
  15. Review
  16. Refining High-Risk Multiple Myeloma: Advancements in Genomic, Clinical, and Prognostic Criteria.Mediterranean journal of hematology and infectious diseases · 2025
    Review
  17. Article
  18. Review
  19. Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

F MauraDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
M PetljakCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
M LionettiDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
I CifolaInstitute for Biomedical Technologies, National Research Council, Milan, Italy.
W LiangIntegrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
E PinatelInstitute for Biomedical Technologies, National Research Council, Milan, Italy.
L B AlexandrovDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
A FullamCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
I MartincorenaCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
K J DawsonCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
N AngelopoulosCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
M K SamurJerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
R SzalatJerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
J ZamoraCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
P TarpeyCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
H DaviesCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
P CorradiniDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
K C AndersonJerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
S MinvielleCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France and CHU de Nantes, Nantes, France.
A NeriDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
H Avet-LoiseauGenomics of Myeloma Laboratory, L'Institut Universitaire du Cancer Oncopole, Toulouse, France.
J KeatsIntegrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
P J CampbellCancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.
N C MunshiJerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
N BolliDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Funding

Targeting Genomic Instability and Evolution in MyelomaP01CA155258 · NCI · DANA-FARBER CANCER INST · PI Nikhil C. Munshi · 2011 to 2026
$32.5M
Cancer Research UK 21777NCI NIH HHS P01 CA155258
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

APOBEC DeaminasesCell Line, TumorHumansLeukemia, Plasma CellMultiple MyelomaMutationParaproteinemiasPrognosisAPOBEC Deaminases

Identifiers

PMID29209044
PMCPMC5886048

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.