ArticleScientific reports2017
HSP60 possesses a GTPase activity and mediates protein folding with HSP10.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How soluble misfolded proteins bypass chaperones at the molecular level.Nature communications · 2023Pooled it
- Conserved HSP60 structure with lineage- and context-specific regulation in cnidarians.Life science alliance · 2026Article
- Metronidazole and ether derivatives target Helicobacter pylori via simultaneous stress induction and inhibition.Nature microbiology · 2026Article
- TRPM4 modulates endothelial inflammation and pyroptosis via the HSP60-NF-κB axis.Frontiers in pharmacology · 2026Article
- Genome-wide characterization and seasonal modulation of Hsp60 expression in juvenile Hilsa Shad across distinct upstream habitats.Journal, genetic engineering & biotechnology · 2025Article
- Mitochondrial Quality Control in Neurodegeneration and Cancer: A Common Denominator, Distinct Therapeutic Challenges.International journal of molecular sciences · 2025Review
- A conservedMicrobiology (Reading, England) · 2025Article
- Advances in the structures, mechanisms and targeting of molecular chaperones.Signal transduction and targeted therapy · 2025Review
- Immunomodulatory Tissue Factors in the Gallbladder Walls of Pediatric Patients with Chronic Calculous Cholecystitis.Children (Basel, Switzerland) · 2025Article
- A new weapon: the application of tumor vaccines based on extracellular exosomal heat shock proteins in immunotherapy.Frontiers in immunology · 2025Review
- Distribution of Immunomodulation, Protection and Regeneration Factors in Cleft-Affected Bone and Cartilage.Diagnostics (Basel, Switzerland) · 2024Article
- Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea.Nucleic acids research · 2024Article
- Mizoribine Promotes Molecular Chaperone HSP60/HSP10 Complex Formation.International journal of molecular sciences · 2024Article
- Low-temperature features of the psychrophilic chaperonin from Pseudoalteromonas haloplanktis.Archives of microbiology · 2024Article
- Review
- Chaperones vs. oxidative stress in the pathobiology of ischemic stroke.Frontiers in molecular neuroscience · 2024Review
- Bioinformatics Analysis, Expression Profiling, and Functional Characterization of Heat Shock Proteins inBioengineering (Basel, Switzerland) · 2023Article
- Article
- Host cell stress response as a predictor of COVID-19 infectivity and disease progression.Frontiers in molecular biosciences · 2022Review
- The Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes.Oxidative medicine and cellular longevity · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian molecular chaperone, HSP60, plays an essential role in protein homeostasis through mediating protein folding and assembly. The structure and ATP-dependent function of HSP60 has been well established in recent studies. After ATP, GTP is the major cellular nucleotide. In this paper, we have investigated the role of GTP in the activity of HSP60. It was found that HSP60 has different properties with respect to allostery, complex formation and protein folding activity depending on the nucleoside triphosphate present. The presence of GTP slightly affected the ATPase activity of HSP60 during protein folding. These results provide clues as to the functional mechanism of the HSP60-HSP10 complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.