ArticleThe Journal of experimental medicine2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
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Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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The trial behind it
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Who cites it
47 citing papers in PubMed, 86 citations in OpenAlex.
- Association of CSF AβNeurology · 2022Trial
- Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Microglia across evolution: from conserved origins to functional divergence.Cellular & molecular immunology · 2025Review
- Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Salivary levels of amyloid beta reflect brain amyloid beta burden in cognitively-normal older adults.The journal of prevention of Alzheimer's disease · 2025Article
- Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Molecular Determinants of Protein Pathogenicity at the Single-Aggregate Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds.Alzheimer's research & therapy · 2025Article
- The curious case of a heterozygous loss-of-functionMolecular neurodegeneration advances · 2025Article
- The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults.Neurobiology of aging · 2024Article
- γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.Annals of neurology · 2024Article
- Distinctive contribution of two additional residues in protein aggregation of Aβ42 and Aβ40 isoforms.BMB reports · 2024Review
- A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies.Molecular therapy. Methods & clinical development · 2023Article
- The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains.Scientific reports · 2023Article
- Dual Efficacy of a Catalytic Anti-Oligomeric Aβ42 scFv Antibody in Clearing Aβ42 Aggregates and Reducing Aβ Burden in the Brains of Alzheimer's Disease Mice.Molecular neurobiology · 2023Article
- H3K27 acetylation-induced FSTL1 upregulation by P300/RUNX1 co-activation exacerbated autophagy-mediated neuronal damage and NF-κB-stimulated inflammation in Alzheimer's disease.Cytotechnology · 2023Article
- Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity.Molecular neurodegeneration · 2023Article
- N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.Cell death & disease · 2023Article
- Eicosapentaenoic Acid Protects against Metabolic Impairments in the APPswe/PS1dE9 Alzheimer's Disease Mouse Model.The Journal of nutrition · 2023Article
- Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Brenda D MooreCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.
Jason MartinCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.ORCID 0000-0001-7552-4456
Lorena de MenaMcKnight Brain Institute, University of Florida, Gainesville, FL.ORCID 0000-0001-7096-0611
Jonatan SanchezMcKnight Brain Institute, University of Florida, Gainesville, FL.
Pedro E CruzCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.
Carolina Ceballos-DiazCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.
Thomas B LaddCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.
Yong RanCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.ORCID 0000-0002-9748-4392
Yona LevitesCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.
Thomas L KukarDepartment of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-3750-6262
Justin J KurianDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL.
Robert McKennaDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL.
Edward H KooDepartment of Neuroscience, University of California, San Diego, La Jolla, CA.
David R BorcheltCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.ORCID 0000-0002-0813-6979
Christopher JanusCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL.
Diego Rincon-LimasMcKnight Brain Institute, University of Florida, Gainesville, FL.ORCID 0000-0003-3099-0642
Pedro Fernandez-FunezDepartment of Biomedical Sciences, University of Minnesota School of Medicine, Duluth, MN.
Todd E GoldeCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL tgolde@mbi.ufl.edu.ORCID 0000-0003-1867-7071
University of Florida · USEmory University · USUniversity of California San Diego · USUniversity of Minnesota, Duluth · US
Funding
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6MUniversity of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8MTARGET IDENTIFICATION AND MECHANISMS OF ACTIONS OF y-SECRETASE MODULATORSP01AG020206 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 2002 to 2013
$13.2MUniversity of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2015 to 2019
$7.3MImmune-Mediated Mechanisms Underlying CNS Abeta ClearanceR01AG018454 · NIA · UNIVERSITY OF FLORIDA · PI GOLDE, TODD E · 2000 to 2018
$5.3MBASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3MDefining the role of FUS phosphorylation in neurodegenerationR01NS093362 · NINDS · EMORY UNIVERSITY · PI KUKAR, THOMAS L · 2015 to 2019
$1.7MHoward Hughes Medical InstituteNIAID NIH HHS T32 AI007110NIA NIH HHS P01 AG020206NIA NIH HHS P30 AG028740NIA NIH HHS P50 AG047266NIA NIH HHS R01 AG018454NIA NIH HHS U01 AG046139NINDS NIH HHS R01 NS093362
Abstract
Processing of amyloid-β (Aβ) precursor protein (APP) by γ-secretase produces multiple species of Aβ: Aβ40, short Aβ peptides (Aβ37-39), and longer Aβ peptides (Aβ42-43). γ-Secretase modulators, a class of Alzheimer's disease therapeutics, reduce production of the pathogenic Aβ42 but increase the relative abundance of short Aβ peptides. To evaluate the pathological relevance of these peptides, we expressed Aβ36-40 and Aβ42-43 in
Indexed as
AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsAnimals, Genetically ModifiedBrainDrosophila melanogasterEyeFemaleLocomotionMiceMice, TransgenicPeptide FragmentsPhenotypeProtein AggregatesProtein Aggregation, PathologicalAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorPeptide FragmentsProtein Aggregates
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.