ArticleJournal of the American Academy of Dermatology2018
Statin use and risk of skin cancer.
Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Association Between Statin Use and Non-Melanoma Skin Cancer Risk: A Distributed Network Analysis of 11 Real-World Databases.Annals of dermatology · 2026Article
- Comparative Study of Cutaneous Squamous Cell Carcinogenesis in Different Hairless Murine Models.Cancers · 2024Article
- Statins are associated with increased risk of squamous cell carcinoma of the skin: a whole-population study from Iceland.Archives of dermatological research · 2022Article
- XGBoost algorithm and logistic regression to predict the postoperative 5-year outcome in patients with glioma.Annals of translational medicine · 2022Article
- Predictive value of immunological markers in systemic sclerosis.Experimental and therapeutic medicine · 2021Article
- Review
- Predicting factors of tumor progression in adult patients with low-grade glioma within five years after surgery.Translational cancer research · 2021Article
- Regression of Periocular Basal Cell Carcinoma: A Report of Four Cases with Clinicopathologic Correlation.Ocular oncology and pathology · 2020Article
- Evaluation of the Association Between Statin Exposure and Skin Cancer: A Nationwide Case-Control Study in South Korea.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStatins are among the most commonly used medications in the United States, and statin use is associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). However, previous studies are limited by lack of adjustment for important confounders.
objectiveExamine the relation between statins and skin cancer risk in the Nurses' Health Study and Health Professionals Follow-up Study.
methodsCox proportional hazards regression was used to evaluate associations.
resultsDuring follow-up (2000-2010), we documented 10,201 BCC, 1393 SCC, and 333 melanoma cases. History of high cholesterol level was not associated with risk of BCC (pooled multivariable-adjusted hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.00-1.09), SCC (HR, 0.95; 95% CI, 0.85-1.06), or melanoma (HR, 0.87; 95% CI, 0.64-1.19). Statin use was not associated with risk of BCC (HR, 1.04; 95% CI, 0.99-1.09]), SCC (HR, 1.08; 95% CI, 0.94-1.24), or melanoma (HR, 1.04; 95% CI, 0.78-1.38). There was a trend toward higher BCC risk with longer duration of statin use in men (P trend = .003) but not in women (P trend = .86). LIMITATIONS: Lack of treatment data.
conclusionHistory of high cholesterol level was not associated with skin cancer risk. Longer duration of statin use was associated with a trend toward higher BCC risk in men.
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Registered trials
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