ArticleEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology2018
Defining the incidence and clinical significance of lymph node metastasis in soft tissue sarcoma.
Article in European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Guideline
- Lymph node metastases in paediatric and young adult patients with non-rhabdomyosarcoma soft tissue sarcoma (NRSTS): Findings from Children's Oncology Group (COG) study ARST0332.European journal of cancer (Oxford, England : 1990) · 2023Trial
- Development, validation, and visualization of a web-based nomogram for predicting the incidence of leiomyosarcoma patients with distant metastasis.Cancer reports (Hoboken, N.J.) · 2022Trial
- Clinical features and outcomes of young patients with epithelioid sarcoma: an analysis from the Children's Oncology Group and the European paediatric soft tissue Sarcoma Study Group prospective clinical trials.European journal of cancer (Oxford, England : 1990) · 2019Trial
- [When and how are pulmonary metastases surgically treated in sarcomas?]Chirurgie (Heidelberg, Germany) · 2026Review
- MRI characteristics of appendicular soft tissue lymphoma: a retrospective analysis.World journal of surgical oncology · 2026Article
- Proposal of a Risk Stratification Algorithm for Extracranial Malignant Rhabdoid Tumors.Cancer medicine · 2026Article
- Incidence, risk factors, and prognostic impact of regional lymph node metastasis in bone sarcoma: a population-based cohort study.Japanese journal of clinical oncology · 2025Article
- Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma Consortium.EClinicalMedicine · 2025Article
- Article
- Histological Type-Specific Behavior in Sarcomas: Analysis of Head and Neck Cancer Registry of Japan.The Laryngoscope · 2025Article
- [Localized soft tissue sarcomas].Chirurgie (Heidelberg, Germany) · 2025Review
- Prognostic significance of lymph node metastasis of soft tissue sarcoma of the extremities. National cancer institute experience.International journal of clinical oncology · 2025Article
- Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma.Clinical & experimental metastasis · 2024Article
- Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center.Current oncology (Toronto, Ont.) · 2024Observational
- Review on Lymph Node Metastases, Sentinel Lymph Node Biopsy, and Lymphadenectomy in Sarcoma.Current oncology (Toronto, Ont.) · 2024Review
- Lymphadenectomy in the treatment of sarcomas - indications and technique.Oncology reviews · 2024Review
- Current topics and management of head and neck sarcomas.Japanese journal of clinical oncology · 2023Review
- Cytological Features of a Metastatic Angiosarcoma in the Lymph Node Diagnosed via Liquid-Based Cytology.Diagnostics (Basel, Switzerland) · 2023Article
- ASO Author Reflections: Variability in Management of Sarcoma Lymph Node Metastases.Annals of surgical oncology · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe incidence and clinical significance of lymph node metastasis (LNM, N1) in soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS (ETSTS). We sought to define the subgroup of patients with LNM at sarcoma diagnosis across all disease sites and histologies.
methodsWe identified and categorized 89,870 STS patients from the National Cancer Data Base (1998-2012) by nodal stage. Pathologically confirmed LNM (pN1) were identified in 1404 patients; 1750 had clinically suspicious but not pathologically confirmed LNM (cN1). Survival analyses were performed by Kaplan-Meier method.
resultsOf 3154 patients (3.5%) with pN1 or cN1 LNM at presentation, 1310 had synchronous distant metastasis (M1). LNM affected a small proportion of patients (5.8% head/neck, 5.3% intrathoracic, 5.1% intra-abdominal, 2.0% ETSTS). Angiosarcoma (6%), epithelioid (13%), clear cell (16%), and small cell sarcoma (19%) had the highest incidence of LNM, although liposarcoma, fibrous histiocytoma, and leiomyosarcoma accounted for the greatest number of LNM patients. For pN1M0 disease, median overall survival (OS) was 28.2 months, varying by histology. Among patients with pN1M0 STS, angiosarcoma, clear cell sarcoma, leiomyosarcoma, and fibrous histiocytoma were associated with worse median OS (19.4, 23.8, 27.1, and 29.3 months) compared to epithelioid sarcoma and liposarcoma (49.6 and 56.0 months, p < 0.001).
conclusionDespite clinical suspicion, pathologic LN evaluation in STS is inconsistently performed. LNM occurs across anatomic disease sites and is unevenly distributed across histologies. Although M1 disease portends poor prognosis regardless of LN status, LNM predicts worse OS in a histology-dependent manner in M0 disease.
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