ArticleMicrobial genomics2017
Novel large-scale chromosomal transfer in Bacteroides fragilis contributes to its pan-genome and rapid environmental adaptation.
Article in Microbial genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Horizontal transfer of chromosomal DNA mediated by an integrative and conjugative element generates frequent localized recombination inJournal of bacteriology · 2026Article
- Gene regulation inMicrobiology and molecular biology reviews : MMBR · 2025Review
- PathogenicbioRxiv : the preprint server for biology · 2024Article
- Article
- Dynamics of bacterial recombination in the human gut microbiome.PLoS biology · 2024Article
- Origins and Evolution of NovelbioRxiv : the preprint server for biology · 2023Article
- Diversity and dynamics of the CRISPR-Cas systems associated with Bacteroides fragilis in human population.BMC genomics · 2022Article
- Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria.mSystems · 2022Article
- Article
- The Infant Gut CommensalFrontiers in cellular and infection microbiology · 2022Article
- Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives.Frontiers in cellular and infection microbiology · 2022Review
- Genomic Background and Phylogeny ofAntibiotics (Basel, Switzerland) · 2021Article
- Strain diversity in the microbiome: Lessons from Bacteroides fragilis.PLoS pathogens · 2020Review
- Streamlined Genetic Manipulation of DiversemBio · 2019Article
- Mycoplasmas under experimental antimicrobial selection: The unpredicted contribution of horizontal chromosomal transfer.PLoS genetics · 2019Article
- Antigenic mimicry of ubiquitin by the gut bacterium Bacteroides fragilis: a potential link with autoimmune disease.Clinical and experimental immunology · 2018Article
- CRISPR-Cas Systems inFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Bacteroides fragilis, an important component of the human gastrointestinal microbiota, can cause lethal extra-intestinal infection upon escape from the gastrointestinal tract. We demonstrated transfer and recombination of large chromosomal segments from B. fragilis HMW615, a multidrug resistant clinical isolate, to B. fragilis 638R. In one example, the transfer of a segment of ~435 Kb/356 genes replaced ~413 Kb/326 genes of the B. fragilis 638R chromosome. In addition to transfer of antibiotic resistance genes, these transfers (1) replaced complete divergent polysaccharide biosynthesis loci; (2) replaced DNA inversion-controlled intergenic shufflons (that control expression of genes encoding starch utilization system outer membrane proteins) with more complex, divergent shufflons; and (3) introduced additional intergenic shufflons encoding divergent Type 1 restriction/modification systems. Conjugative transposon-like genes within a transferred segment and within a putative integrative conjugative element (ICE5) ~45 kb downstream from the transferred segment both encode proteins that may be involved in the observed transfer. These data indicate that chromosomal transfer is a driver of antigenic diversity and nutrient adaptation in Bacteroides that (1) contributes to the dissemination of the extensive B. fragilis pan-genome, (2) allows rapid adaptation to a changing environment and (3) can confer pathogenic characteristics to host symbionts.
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