Evidence map›Paper›PMID 29208010›Full record

Observational studyArthritis research & therapy2017

Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study.

Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hiroaki Yoshida, Robin Poole, Naoki Ishiguro

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  8. Coaction of TGF-β1 and CDMP1 in BMSCs-induced laryngeal cartilage repair in rabbits.Journal of materials science. Materials in medicine · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yasumori SobueDepartment of Orthopedic Surgery, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.
Toshihisa KojimaDepartment of Orthopedic Surgery, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan. toshik@med.nagoya-u.ac.jp.
Kazutoshi KurokouchiOrthopedic Surgery, Mitsubishi Nagoya Hospital, 7-8 Sotodoi, Atsuta, Nagoya, 456-0013, Japan.
Shigeo TakahashiOrthopedic Surgery, Mitsubishi Nagoya Hospital, 7-8 Sotodoi, Atsuta, Nagoya, 456-0013, Japan.
Hiroaki YoshidaOrthopedic Surgery, Kamiiida Daiichi General Hospital, 2-70 Kamiiidakita, Kita, Nagoya, 462-0802, Japan.
Robin PooleDivision of Orthopaedics, Department of Surgery, McGill University, Montreal, QC, Canada.
Naoki IshiguroDepartment of Orthopedic Surgery, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.

Funding

Japan Society for the Promotion of Science 26462290
6 · The paper itself

Abstract

backgroundWe aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction.

methodsArthroscopic assessment of articular cartilage damage was performed twice in 62 patients, first during ACL reconstruction and then approximately 2 years later during implant removal for ligament fixation. SF levels of the collagenase-generated cleavage neoepitope of type II collagen (C2C) and proteoglycan glycosaminoglycans keratan sulfate (KS), chondroitin-4-sulfate (Δdi-C4S), and chondroitin-6-sulfate (Δdi-C6S) were measured at ACL reconstruction. Associations between baseline biomarker levels and subsequent progression of cartilage damage were determined using receiver operating characteristic analysis and multivariable logistic regression analysis.

resultsNo radiographic changes were observed in any of the patients. Progression of high-grade cartilage damage, observed arthroscopically, was negatively correlated with levels of Δdi-C6S and KS, as well as the ratio of Δdi-C6S to Δdi-C4S (C6S/C4S). Logistic regression analysis revealed significant associations of Δdi-C6S (cut-off: 55.7 nmol/ml, odds ratio (OR) 0.231, 95% confidence interval (CI) 0.061-0.879), KS (cut-off: 10.6 μg/ml, OR 0.114, 95% CI 0.024-0.529), and C6S/C4S ratio (cut-off: 4.6, OR 0.060, 95% CI 0.005-0.737) with the progression of high-grade cartilage damage after adjusting for age, the duration from injury to first surgery, sex, and the number of high-grade lesions (grades III and IV) at baseline.

conclusionsThe progression of high-grade cartilage damage was significantly associated with baseline levels of proteoglycan glycosaminoglycan biomarkers; namely, Δdi-C6S, KS, and C6S/C4S ratio.

Indexed as

AdultAggrecansAnterior Cruciate Ligament ReconstructionBiomarkersCartilage, ArticularCollagen Type IIDisease ProgressionFemaleHumansMalePostoperative ComplicationsRetrospective StudiesSynovial FluidYoung AdultACAN protein, humanAggrecansBiomarkersCollagen Type IIAnterior cruciate ligament injuryArthroscopyBiomarkerCartilageChondroitin sulfateKeratan sulfate

Identifiers

PMID29208010
PMCPMC5718025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.