Evidence map›Paper›PMID 29207833›Full record

ArticleJournal of clinical and diagnostic research : JCDR2017

Possible Role of Bcl-2 Expression in Metastatic and Non Metastatic Oral Squamous Cell Carcinoma.

V Pavithra, Karuna Kumari, Vanishri C Haragannavar, Roopa S Rao, Shwetha Nambiar, Dominic Augustine, S V Sowmya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Tumor invasion front in oral squamous cell carcinoma.World journal of clinical cases · 2022
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

V PavithraPostgraduate, Department of Oral Pathology, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Karuna KumariPostgraduate, Department of Oral Pathology, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Vanishri C HaragannavarAssistant Professor, Department of Oral Pathology, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Roopa S RaoProfessor and Head, Department of Oral Pathology, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Shwetha NambiarTutor, Department of Oral Pathology, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Dominic AugustineAssistant Professor, Department of Oral Pathology, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
S V SowmyaAssociate Professor, Department of Oral Pathology, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
M S Ramaiah University of Applied Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOral carcinoma is a global health problem. India accounts for one-third of world burden with high prevalence rate of 2.5 million and mortality rate of 5.5 lacs per year. Oral carcinogenesis is a multistage process that frequently involves invasion and metastasis that needs early detection and treatment to improve the overall quality of life. The ability of Oral Squamous Cell Carcinoma (OSCC) to metastasize to lymph nodes does not always show a relationship with clinical staging. A spectrum of molecular mechanisms is involved in carcinogenesis, where defect in the regulation of apoptosis is assumed to contribute to the pathogenesis and progression of cancer. Apoptosis regulatory genes include the antiapoptotic protein such as B-cell lymphoma-2 (Bcl-2) gene that might be used as a molecular marker to evaluate the biological behaviour of oral cancer.

aimTo evaluate and correlate the Bcl-2 expression in OSCC patients with lymphnode metastasis and without metastasis. MATERIALS AND

methodsThe study comprised of 30 samples, 15 cases of metastatic and 15 non-metastatic primary OSCC. All the cases were stained for routine Hematoxylin and Eosin (H&E), and Bcl-2 antibody by immunohistochemistry. The H&E stained sections were evaluated for Lymphocytic Infiltrate (LI) and Pattern Of Invasion (POI). Bcl-2 stained sections were evaluated for staining intensity and distribution. The differences between the groups were statistically analysed using chi-square test.

resultsThe histopathological parameters, LI and POI did not show any statistical difference between the study groups. Expression of Bcl-2 in OSCC was 33.3% among the study groups, where metastatic group showed a positive expression of 13.3% and 20% in non-metastatic OSCC that did not show statistically significance among the study groups.

conclusionThere was no significant difference in the expression of Bcl-2 between the study groups. Apoptosis is regulated by interaction among the Bcl-2 gene family. Hence, evaluation of Bcl-2 along with other apoptotic regulating proteins could define the role in pathogenesis and prognosis of metastatic and non-metastatic OSCC.

Indexed as

ApoptosisMetastasisNeoangiogenesis

Identifiers

PMID29207833
PMCPMC5713855
OpenAlexW2766474315

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.