ArticleJournal of clinical and diagnostic research : JCDR2017
Correlation of Trace Elements in Patients of Chronic Liver Disease with Respect to Child- Turcotte- Pugh Scoring System.
Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Dysregulation of Trace Elements in Pediatric Cholestasis: From Pathophysiology to Nutritional Approaches.International journal of molecular sciences · 2026Review
- Effect of an acute bout of endurance eccentric exercise on exerkines production in healthy males.European journal of applied physiology · 2026Article
- Altered trace elements, antioxidant vitamin C, and malondialdehyde levels are associated with the pathophysiology and development of pre-hepatic jaundice: A case-control study.SAGE open medicine · 2024Article
- Nutritional Support for Liver Diseases.Nutrients · 2023Review
- Trace Element Imbalances in Acquired Hepatocerebral Degeneration and Changes after Liver Transplant.Biology · 2023Article
- Article
- The Study of the Aorta Metallomics in the Context of Atherosclerosis.Biomolecules · 2021Article
- Malnutrition in Patients with Liver Cirrhosis.Nutrients · 2021Review
- Copper Deficiency in Liver Diseases: A Case Series and Pathophysiological Considerations.Hepatology communications · 2019Article
- Micronutrient Deficiencies in Medical and Surgical Inpatients.Journal of clinical medicine · 2019Review
- Nutritional issues in patients with obesity and cirrhosis.World journal of gastroenterology · 2018Review
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionZinc, copper, manganese and magnesium are essential trace elements whose role in chronic liver disease and its complications is not clear.
aimTo study the concentration of these elements in patients with Chronic Liver Disease (CLD) with respect to Child-Torcotte-Pugh (CTP) scoring. MATERIALS AND
methodsThis was an observational study carried out in the Department of Medicine, JSS Hospital, Mysore, India, between October 2013 and October 2015. A total of 75 patients with cirrhosis were prospectively enrolled. Severity of liver disease was assessed based on CTP score and patients were grouped into Class A, B and C. Routine investigations were done and following trace elements were assessed in all-zinc, copper, manganese and magnesium.
resultsThe serum concentrations of zinc decreased with severity of liver disease, and the mean difference between different severity classes was statistically significant (p<0.001). There was a significant negative correlation between zinc and CTP Score (r= -0.439; p<0.001). Copper concentration was increased in patients with more severe cirrhosis and mean level difference of copper among the CTP groups were statistically significant (p<0.001). Moreover, copper showed significant positive correlation with CTP Score (r=0.385; p<0.001). The serum levels of manganese were significantly higher in patients with CTP C class in comparison to patients with CTP A and B class (p<0.05); Manganese showed significant positive correlation with CTP Score (r=0.271; p= 0.019). The concentrations of magnesium did not differ significantly between CTP class with the mean level difference not statistically significant.
conclusionIncreasing liver dysfunction alters the metabolism of trace elements towards excess of copper and deficiency of zinc.
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