ReviewSensors (Basel, Switzerland)2017
Recent Advances in Fluorescence Lifetime Analytical Microsystems: Contact Optics and CMOS Time-Resolved Electronics.
Review in Sensors (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An FPGA-Based Event-Timing Front-End for Time-Resolved Sensing with Dual-Mode Experimental Characterization.Sensors (Basel, Switzerland) · 2026Article
- Applications of Fluorescence Technology for Rapid Identification of Marine Plastic Pollution.Polymers · 2025Review
- Electronic Tongues and Noses: A General Overview.Biosensors · 2024Review
- Microfluidics-Based Nanobiosensors for Healthcare Monitoring.Molecular biotechnology · 2024Review
- Applications of machine learning in time-domain fluorescence lifetime imaging: a review.Methods and applications in fluorescence · 2024Review
- Positive role of the long luminescence lifetime of upconversion nanophosphors on resonant surfaces for ultra-compact filter-free bio-assays.Biomedical optics express · 2021Article
- Turning Image Sensors into Position and Time Sensitive Quantitative Colorimetric Data Sources with the Aid of Novel Image Processing/Analysis Software.Sensors (Basel, Switzerland) · 2020Article
- Analytical Study of Front-End Circuits Coupled to Silicon Photomultipliers for Timing Performance Estimation under the Influence of Parasitic Components.Sensors (Basel, Switzerland) · 2020Article
- Optofluidic Formaldehyde Sensing: Towards On-Chip Integration.Micromachines · 2020Article
- Article
- A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer.Chemical science · 2020Article
- New luminescence lifetime macro-imager based on a Tpx3Cam optical camera.Biomedical optics express · 2020Article
- Deciphering the Binding Mechanism of Noscapine with Lysozyme: Biophysical and Chemoinformatic Approaches.ACS omega · 2019Article
- A Low-Cost Time-Correlated Single Photon Counting Portable DNA Analyzer.Sensors (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence spectroscopy has become a prominent research tool with wide applications in medical diagnostics and bio-imaging. However, the realization of combined high-performance, portable, and low-cost spectroscopic sensors still remains a challenge, which has limited the technique to the laboratories. A fluorescence lifetime measurement seeks to obtain the characteristic lifetime from the fluorescence decay profile. Time-correlated single photon counting (TCSPC) and time-gated techniques are two key variations of time-resolved measurements. However, commercial time-resolved analysis systems typically contain complex optics and discrete electronic components, which lead to bulkiness and a high cost. These two limitations can be significantly mitigated using contact sensing and complementary metal-oxide-semiconductor (CMOS) implementation. Contact sensing simplifies the optics, whereas CMOS technology enables on-chip, arrayed detection and signal processing, significantly reducing size and power consumption. This paper examines recent advances in contact sensing and CMOS time-resolved circuits for the realization of fully integrated fluorescence lifetime measurement microsystems. The high level of performance from recently reported prototypes suggests that the CMOS-based contact sensing microsystems are emerging as sound technologies for application-specific, low-cost, and portable time-resolved diagnostic devices.
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Registered trials
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