SynthesisJournal of preventive medicine and public health = Yebang Uihakhoe chi2017
Congenital Malformations in Infants of Mothers Undergoing Assisted Reproductive Technologies: A Systematic Review and Meta-analysis Study.
Synthesis in Journal of preventive medicine and public health = Yebang Uihakhoe chi, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Maternal and neonatal outcomes of dichorionic twin pregnancies achieved with assisted reproductive technology: meta-analysis of contemporary data.Journal of assisted reproduction and genetics · 2024Pooled it
- Risk of minor congenital heart defect in infants conceived via assisted reproductive technology: cohort study from the Copenhagen Baby Heart Study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Pregnancy and perinatal complications in untreated subfertile couples following singleton spontaneous conception: a narrative review.Reproductive biology and endocrinology : RB&E · 2026Review
- Does assisted reproductive technology influence the complexity and associated malformations in esophageal atresia?Journal of assisted reproduction and genetics · 2025Article
- [Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024Article
- Diagnosis and management of infertility: NICE-adapted guidelines from the Italian Society of Human Reproduction.Reproductive biology and endocrinology : RB&E · 2024Article
- Long-Term Effects of ART on the Health of the Offspring.International journal of molecular sciences · 2023Review
- In vitro fertilization as an independent risk factor for perinatal complications: Single-center 10 years cohort study.JBRA assisted reproduction · 2023Article
- The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors.Current oncology (Toronto, Ont.) · 2022Article
- Epigenetic Effect of Maternal Methyl-Group Donor Intake on Offspring's Health and Disease.Life (Basel, Switzerland) · 2022Review
- Society for Maternal-Fetal Medicine Consult Series #60: Management of pregnancies resulting from in vitro fertilization.American journal of obstetrics and gynecology · 2022Article
- Maternal effect genes: Update and review of evidence for a link with birth defects.HGG advances · 2022Review
- Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies.Journal of cancer survivorship : research and practice · 2021Article
- In Vitro Fertilization Technology and Child Health.Deutsches Arzteblatt international · 2020Review
- Epigenetics and Neurological Disorders in ART.International journal of molecular sciences · 2019Review
- Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study.Italian journal of pediatrics · 2019Article
- Repeated use of medications for ovulation induction after unsuccessful treatment: A cause of concern for infertile couples.International journal of reproductive biomedicine · 2019Article
- Risks of neonatal anomalies and obstetric complications in 7378 singleton births after frozen-thawed and fresh embryo transfers in Japan: An analysis using doubly robust estimation.Reproductive medicine and biologyArticle
- Eye anomalies in children born through ART.Romanian journal of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis meta-analysis aimed to evaluate congenital malformations in infants conceived by assisted reproductive techniques (ART), compared with infants conceived spontaneously.
methodsIn this study, available resources searched to find relevant articles included PubMed, ScienceDirect, Scopus, Google Scholar, Cochrane, ProQuest, Iranmedex, Magiran, and Scientific Information Database. After extracting the necessary information from evaluated articles, meta-analysis on the articles' data was performed using Stata version 11.2.
resultsIn this study, from a total of 339 articles, extracted from the initial investigation, ultimately 30 articles were selected for meta-analysis that assessed the use of ART on the risk of congenital abnormalities and some birth complications on 5 470 181 infants (315 402 cases and 5 154 779 controls). The odds ratio (95% confidence interval [CI]) for low birth weight was 1.89 (95% CI, 1.36 to 2.62), preterm labor 1.79 (95% CI, 1.21 to 2.63), cardiac abnormalities 1.43 (95% CI, 1.27 to 1.62), central nervous system abnormalities 1.36 (95% CI, 1.10 to 1.70), urogenital system abnormalities 1.58 (95% CI, 1.28 to 1.94), musculoskeletal disorders 1.35 (95% CI, 1.12 to 1.64), and chromosomal abnormalities in infants conceived by ART was 1.14 (95% CI, 0.90 to 1.44), which were all statistically significant, except chromosomal abnormalities.
conclusionsThe risk of congenital abnormalities and some birth complications were significantly higher in ART than normal conception, while chromosomal abnormalities were not; therefore, the application of ART should be selected individually for patients by detailed assessment to reduce such risks in the population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.