Evidence map›Paper›PMID 29207309›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2018

Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases.

Madhu Sundaraneedi, Ramon M Eichenberger, Rafid Al-Hallaf, Dai Yang, Javier Sotillo, Siji Rajan, Phurpa Wangchuk, Paul R Giacomin, F Richard Keene, Alex Loukas and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.Metabolomics : Official journal of the Metabolomic Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Madhu SundaraneediSchool of Physical, Environmental and Mathematical Sciences, UNSW (ADFA), Canberra, Australian Capital Territory, 2612, Australia.
Ramon M EichenbergerCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
Rafid Al-HallafCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
Dai YangCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
Javier SotilloCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
Siji RajanSchool of Physical, Environmental and Mathematical Sciences, UNSW (ADFA), Canberra, Australian Capital Territory, 2612, Australia.
Phurpa WangchukCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
Paul R GiacominCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
F Richard KeeneCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia; School of Physical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Alex LoukasCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia.
J Grant CollinsSchool of Physical, Environmental and Mathematical Sciences, UNSW (ADFA), Canberra, Australian Capital Territory, 2612, Australia.
Mark S PearsonCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, 4878, Australia. Electronic address: mark.pearson@jcu.edu.au.
Australian Institute of Tropical Health and Medicine · AUAustralian Defence Force Academy · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over 4.5 billion people are at risk of infection with soil transmitted helminths and there are concerns about the development of resistance to the handful of frontline nematocides in endemic populations. We investigated the anti-nematode efficacy of a series of polypyridylruthenium(II) complexes and showed they were active against L3 and adult stages of Trichuris muris, the rodent homologue of the causative agent of human trichuriasis, T. trichiura. One of the compounds, Rubb

Indexed as

AcetylcholinesteraseAdministration, OralAnimalsAntinematodal AgentsCholinesterase InhibitorsDisease Models, AnimalLarvaMaleMiceParasite Egg CountRutheniumTrichuriasisTrichurisAcetylcholinesteraseAntinematodal AgentsCholinesterase InhibitorsRutheniumAcetylcholinesteraseAnthelminticRuthenium complexTrichuris muris

Identifiers

PMID29207309
PMCPMC5724747
OpenAlexW2768654822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.