ArticleMolecular medicine reports2018
The antibacterial effect of topical ozone on the treatment of MRSA skin infection.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 129 citations in OpenAlex.
- A Clinical Trial to Evaluate the Efficacy of α-Viniferin inPolish journal of microbiology · 2021Trial
- SIOOTAntibiotics (Basel, Switzerland) · 2026Article
- Effectiveness of cold atmospheric plasma on Staphylococcus Aureus colonies on living animal tissue surface.PloS one · 2026Article
- Evaluation of the Preoperative Antiseptic Efficacy of Ozone on Dog Skin in Comparison with Traditional Methods.Veterinary sciences · 2025Article
- Physico-Chemical and Antimicrobial Evaluation of Ozonated Olive Oil Produced with a Medical-Grade Generator for Veterinary Purposes.Microorganisms · 2025Article
- Topical ozone application for severe acne with serological evidence of prior varicella-zoster infection after unsuccessful antibiotic and corticosteroid treatment: a case report.Journal of medical case reports · 2025Article
- Management of neurotrophic corneal ulcer with a topical liposomal ozonated oil: A report on three clinical cases.American journal of ophthalmology case reports · 2025Article
- Ozonated Sunflower Oil Stimulates the Local Antioxidant System and Helps Meglumine Antimoniate to Ameliorate Cutaneous Leishmaniasis Lesions.ACS omega · 2025Article
- Pharmacological activities and phytochemical evaluation of coconut crude oil and upon exposure to ozone.AMB Express · 2025Article
- Article
- Effect of ozonation on the phytochemicals of black seed oil and its anti-microbial, anti-oxidant, anti-inflammatory, and anti-neoplastic activities in vitro.Scientific reports · 2024Article
- Liposomal Ozonated Oil Ensures a Further Reduction in the Microbial Load Before Intravitreal Injection: the "OPERA" Study.Ophthalmology and therapy · 2024Article
- Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review).Biomedical reports · 2024Review
- Evaluation of the restorative effect of ozone and chitosan-hyaluronic acid with and without mesenchymal stem cells on wound healing in rats.Veterinary medicine and science · 2024Article
- Bioactive Dressing: A New Algorithm in Wound Healing.Journal of clinical medicine · 2024Review
- Novel synergistic interactions between monolaurin, a mono-acyl glycerol and β lactam antibiotics against Staphylococcus aureus: an in vitro study.BMC infectious diseases · 2024Article
- In vitro and ex vivo anti-Pythium insidiosum potential of ozonated sunflower oil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Physico-Chemical Investigation and Antimicrobial Efficacy of Ozonated Oils: The Case Study of Commercial Ozonated Olive and Sunflower Seed Refined Oils.Molecules (Basel, Switzerland) · 2024Article
- Successful treatment of severe and recurrent hand eczema with infection in human immunodeficiency virus patients: A case report.SAGE open medical case reports · 2024Article
- Effective degradation of various bacterial toxins using ozone ultrafine bubble water.PloS one · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin can be infected by many types of microorganisms, most commonly by gram‑positive strains of Staphylococcus and Streptococcus spp. Treatment of Staphylococcus aureus (S. aureus) infections, particularly that of methicillin resistant Staphylococcus aureus (MRSA), is a challenge in clinical practice. Ozone therapy has proven to be one of the strongest antiseptics against the majority of microorganisms involved in skin infections. The purpose of the present study was to evaluate the microbicidal effects of topical ozone therapy on S. aureus and MRSA, and determine the clinical efficacy of ozone therapy on patients with MRSA skin infection. Microbicidal effects of ozonated oil and ozonated water were determined by plating and Kirby Bauer methods. Clinical efficacy and safety of topical ozone were evaluated in two cases with skin MRSA infection. The killing rates of ozonated oil for S. aureus and MRSA were greater when compared with the control oil group. Almost 100% of S. aureus were eliminated by ozonated oil following 5 min. Almost 100% MRSA were eliminated by ozonated oil following 15 min. In addition, 100% S. aureus and 100% MRSA were eliminated by ozonated water in 1 min. The inhibition zone diameters of ozonated oil for S. aureus and MRSA were 17 and 13 mm, respectively, which were significantly larger than the control group. Both cases of skin MRSA infection were completely healed with ozone therapy. In conclusion, ozone therapy is a potential treatment for S. aureus and MRSA skin infection as it has great efficacy, few side effects and low‑costs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.