ArticleInternational journal of molecular medicine2018
Comparative analysis of human embryonic stem cell‑derived neural stem cells as an in vitro human model.
Article in International journal of molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Heparan Sulfate Proteoglycans as Potential Markers for In Vitro Human Neural Lineage Specification.Cells · 2025Article
- Transcriptomic characterization of maturing neurons from human neural stem cells across developmental time points.IBRO neuroscience reports · 2025Article
- A Human Embryonic Stem Cell-derived Neural Stem Cell Senescence Model Triggered by Oxidative Stress.Current stem cell research & therapy · 2025Article
- Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic.Translational stroke research · 2024Review
- Article
- Pluripotent stem cell-derived neural progenitor cells can be used to model effects of IL-6 on human neurodevelopment.Disease models & mechanisms · 2023Article
- Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles.ACS nano · 2022Article
- Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells.APL bioengineering · 2021Review
- Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100.Journal of nanobiotechnology · 2021Article
- Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia.Theranostics · 2021Article
- Stem Cell Therapies for Progressive Multiple Sclerosis.Frontiers in cell and developmental biology · 2021Review
- Article
- Optimizing Stem Cell Therapy after Ischemic Brain Injury.Journal of stroke · 2020Review
- Regeneration of sciatic nerves by transplanted microvesicles of human neural stem cells derived from embryonic stem cells.Cell and tissue banking · 2020Article
- In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia.Biomolecules · 2020Review
- Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips.Journal of visualized experiments : JoVE · 2019Article
- Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.Nature communications · 2018Article
- Isolation, Culture, and Functional Characterization of Human Embryonic Stem Cells: Current Trends and Challenges.Stem cells international · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternative cell models of human neural stem cells (hNSCs) have been developed and used for investigations ranging from in vitro experiments to in vivo clinical studies. However, a cell model capable of mimicking the 'normal' state of hNSCs is mandatory in order to extrapolate the results of these studies to humans. In the present study, to select a more suitable hNSC model for developing human‑based experimental platforms, two representative hNSC types were compared, namely human embryonic stem cell (hESC)‑derived hNSCs and ReNcell CX cells, which are well‑characterized immortalized hNSC lines. The hNSCs, differentiated from hESCs via human neuroectodermal sphere (hNES) formation, recapitulated the molecular and cellular phenotypes of hNSCs, including NSC marker expression and terminal neuronal differentiation potential. Comparative analyses of the transcriptome profiles of the hESC‑derived hNESs and ReNcell CX hNSCs showed that the differentiated hNESs were analogous to the ReNcell CX cells, as demonstrated by principal component analysis and hierarchical sample clustering. The hNSC‑specific transcriptome was presented, comprising commonly expressed transcripts between hNESs derived from hESCs and ReNcell CX cells. To elucidate the molecular mechanisms associated with the hNSC identity, the hNSC‑specific transcriptome was analyzed using pathway and functional annotation clustering analyses. The results suggested that hESC‑derived hNESs, an expandable and accessible cell source, may be used as a relevant hNSC model in a wide range of neurological investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.