ArticlePain medicine (Malden, Mass.)2018
Longitudinal Relationship Between Knee Pain Status and Incident Frailty: Data from the Osteoarthritis Initiative.
Article in Pain medicine (Malden, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Immunological Insights into the Causal Link Between Arthritis, Osteoarthritis, and Frailty: An Integrated Analytical Study.International journal of medical sciences · 2025Pooled it
- Association between frailty and chronic pain among older adults: a systematic review and meta-analysis.European geriatric medicine · 2020Pooled it
- Feasibility of a yoga intervention to decrease pain in older women: a randomized controlled pilot study.BMC geriatrics · 2020Trial
- Frailty is associated with lower-limb osteoarthritis incidence over six-years regardless of sex and type of frailty index in the Canadian longitudinal study on aging.Osteoarthritis and cartilage open · 2026Article
- Performance-Based and Self-Reported Frailty in Older Adults with or Without Fibromyalgia.European journal of investigation in health, psychology and education · 2026Article
- Effects of an oral exercise intervention on pre-frailty or frailty in older people: a randomized clinical trial.Communications medicine · 2026Article
- Pain characteristics and incident frailty in community-dwelling older adults: dose-response relationships and sex differences in a longitudinal study on aging in Taiwan.Frontiers in public health · 2026Article
- From age to frailty: redefining chronic pain characterization.Aging clinical and experimental research · 2025Article
- The bidirectional relationship between knee osteoarthritis and frailty in China: A longitudinal study.The Journal of frailty & aging · 2025Article
- Is the experience of chronic pain different in frail older adults? A cross-sectional exploratory study.Arquivos de neuro-psiquiatria · 2025Article
- The relation between radiographic knee osteoarthritis severity and pain is stronger among more frail people.Clinical rheumatology · 2025Article
- Longitudinal association between frailty and pain in three prospective cohorts of older population.The journal of nutrition, health & aging · 2025Article
- Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Association between frailty and postherpetic neuralgia in the older adult with herpes zoster.Frontiers in public health · 2025Article
- Associations among frailty conditions and pain indicators: Data from 22 356 European older adults.Geriatrics & gerontology international · 2024Observational
- Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.Aging clinical and experimental research · 2024Article
- Development and validation of a frailty index for use in the osteoarthritis initiative.Age and ageing · 2024Article
- The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England.BMC geriatrics · 2024Article
- Impact of frailty severity and severe pain on cognitive function for community-dwelling older adults with arthritis: a cross-sectional study in Korea.Scientific reports · 2024Article
- Frailty predicts knee pain trajectory over 9 years: results from the Osteoarthritis Initiative.Pain medicine (Malden, Mass.) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Objective: Examine the longitudinal association between knee pain and prefrailty/frailty. Design: Longitudinal study. Setting: Five clinical centers across the United States. Subject: Data from 3,053 nonfrail participants aged 45-79 years at baseline from the Osteoarthritis Initiative. Methods: According to self-reported knee pain at baseline, the participants were placed into three groups: no knee pain (N = 1,600), unilateral knee pain (N = 822), and bilateral knee pain (N = 631). Frailty status was assessed over time using the five frailty indicators (unintentional weight loss, exhaustion, weak energy, slow gait speed, and little physical activity). Based on the number of frailty indicators present, prefrailty (1-2) and frailty (≥3) were diagnosed. Generalized estimating equations logistic regression analyses were conducted to examine the relationship between knee pain status and prefrailty/frailty. Results: After adjusting for age, sex, race, education, marital status, smoking status, comorbidities, and body mass index, unilateral knee pain at baseline was associated with an increased odds of developing prefrailty (odds ratio [OR] = 1.14, 95% confidence interval [CI] = 1.01-1.27) and frailty (OR = 1.89, 95% CI = 1.38-2.62), and bilateral knee pain at baseline was also associated with an increased risk of prefrailty (OR = 1.41, 95% CI = 1.24-1.62) and frailty (OR = 2.21, 95% CI = 1.63-3.01) over time in comparison with no knee pain. The interaction of knee pain status by time was not significantly associated with either prefrailty or frailty. Conclusions: Knee pain (particularly bilateral knee pain) is associated with an increased risk of developing prefrailty and frailty over time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.