Evidence map›Paper›PMID 29206986›Full record

ArticleAmerican journal of epidemiology2017

Potential for Bias When Estimating Critical Windows for Air Pollution in Children's Health.

Ander Wilson, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Robert O Wright, Rosalind J Wright, Brent A Coull

Abstract read
In one paragraph

Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Multi-Tree Model for Precision Environmental Health with Longitudinally Assessed Mixture Exposure.Journal of the Royal Statistical Society. Series C, Applied statistics · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Pre- and postnatal exposure to PMEnvironmental research · 2026
    Article
  10. Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Association of PMPaediatric and perinatal epidemiology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ander WilsonDepartment of Statistics, Colorado State University, Fort Collins, Colorado.
Yueh-Hsiu Mathilda ChiuDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Hsiao-Hsien Leon HsuDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Rosalind J WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Funding

Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUG3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARROLL, KECIA NICOLE, WRIGHT, ROBERT O · 2016 to 2024
$20.6M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
GRADUATE TRAINING IN BIOSTATISTICST32ES007142 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$11.9M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Stress, Environment, and Genetics in Urban AsthmaR01HL080674 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2005 to 2014
$7.0M
Statistical Methods for the Spatio-Temporal Assessment of Social Disparities in CancerP01CA134294 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANEUSE, SEBASTIEN, HERNAN, MIGUEL · 2008 to 2017
$6.8M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
MULTI-LEVEL ANALYSIS OF URBAN CHILDHOOD ASTHMA RISKR01ES010932 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2000 to 2004
$3.0M
Ambient Air Pollution and Incident StrokeR01ES020871 · NIEHS · BROWN UNIVERSITY · PI WELLENIUS, GREGORY A · 2012 to 2016
$2.7M
NCI NIH HHS P01 CA134294NHLBI NIH HHS R01 HL080674NHLBI NIH HHS U01 HL072494NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES010932NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES020871NIEHS NIH HHS T32 ES007142NIH HHS UG3 OD023286NIH HHS UG3 OD023337NIH HHS UH3 OD023286NIH HHS UH3 OD023337
6 · The paper itself

Abstract

Evidence supports an association between maternal exposure to air pollution during pregnancy and children's health outcomes. Recent interest has focused on identifying critical windows of vulnerability. An analysis based on a distributed lag model (DLM) can yield estimates of a critical window that are different from those from an analysis that regresses the outcome on each of the 3 trimester-average exposures (TAEs). Using a simulation study, we assessed bias in estimates of critical windows obtained using 3 regression approaches: 1) 3 separate models to estimate the association with each of the 3 TAEs; 2) a single model to jointly estimate the association between the outcome and all 3 TAEs; and 3) a DLM. We used weekly fine-particulate-matter exposure data for 238 births in a birth cohort in and around Boston, Massachusetts, and a simulated outcome and time-varying exposure effect. Estimates using separate models for each TAE were biased and identified incorrect windows. This bias arose from seasonal trends in particulate matter that induced correlation between TAEs. Including all TAEs in a single model reduced bias. DLM produced unbiased estimates and added flexibility to identify windows. Analysis of body mass index z score and fat mass in the same cohort highlighted inconsistent estimates from the 3 methods.

Indexed as

Infant HealthAir PollutionBiasBostonComputer SimulationConfounding Factors, EpidemiologicFemaleHumansInfantLinear ModelsMaleMaternal ExposureParticulate MatterPregnancyPregnancy OutcomePregnancy TrimestersParticulate Matterair pollutionchildren’s healthconfounding biascritical windowsdistributed lag modelsseasonality

Identifiers

PMID29206986
PMCPMC5860147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.