Evidence map›Paper›PMID 29206677›Full record

ArticleAnnals of surgery2019

Benchmarking Complications Associated with Esophagectomy.

Donald E Low, Madhan Kumar Kuppusamy, Derek Alderson, Ivan Cecconello, Andrew C Chang, Gail Darling, Andrew Davies, Xavier Benoit D'Journo, Suzanne S Gisbertz, S Michael Griffin and 17 more

4 registry-linked trialsOpen access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 410 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
410citing papers in PubMed, 13 pooled it
45.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03541629 completednot on this map

Validation of the Data Quality and Early Outcomes of the Spanish EURECCA Esophagogastric Cancer Registry

TypeobservationalSponsorParc de Salut MarRan2018 to 2020Enrolled1,839ConditionsCancer of Stomach, Cancer of Esophagus
NCT04750096 unknown statusnot on this mapstarted 2020, after this paper: background citation

Respiratory Failure in Esophagectomy. Results After Implantation of Enhanced Recovery After Surgery Protocol.

TypeobservationalSponsorRaquel Ferrandis ComesRan2020 to 2022Enrolled100ConditionsEsophagectomy
NCT06642506 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Oncometabolome and MALDI-MSI in Upper GI Carcinomas - Chemosensitivity in Esophageal Carcinoma.

TypeobservationalSponsorLudwig-Maximilians - University of MunichRan2024 to 2025Enrolled20ConditionsEsophagus Adenocarcinoma, Esophagus Cancer, Metabolome, Mass Spectrometry
NCT07713888 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Multimodal Prehabilitation on Post-operative Recovery in Patients Undergoing Surgery for Upper Gastrointestinal Tract Cancer in Taiwan

TypeinterventionalSponsorTaichung Tzu Chi HospitalRan2026 to 2027Enrolled40ConditionsSurgery of Upper Gastrointestinal Tract CancerArmsPrehabilitation
3 · Its place in the literature

Who cites it

410 citing papers in PubMed, 13 syntheses or guidelines pooled it, 839 citations in OpenAlex.

  1. Pooled it
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  4. Post-esophagectomy hiatal hernias: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2026
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  6. Health-related quality of life in esophageal cancer: a state-of-the-art review of patient-reported outcomes and an evidence and gap map.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
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350 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 15 institutions in 14 countries.

Donald E LowVirginia Mason Medical Center, Seattle, WA.
Madhan Kumar KuppusamyVirginia Mason Medical Center, Seattle, WA.
Derek AldersonDepartment of Surgery, University of Birmingham, Birmingham, UK.
Ivan CecconelloUniversity of São Paulo, São Paulo, Brazil.
Andrew C ChangUniversity of Michigan Health System, Ann Arbor, MI.
Gail DarlingToronto General Hospital, Toronto, Ontario, Canada.
Andrew DaviesSt. Thomas' Hospital, London, UK.
Xavier Benoit D'JournoNorth Hospital - Aix Marseille University, Marseille, France.
Suzanne S GisbertzAcademic Medical Center, Amsterdam, The Netherlands.
S Michael GriffinNorthern Oesophagogastric Unit, Newcastle upon Tyne, UK.
Richard HardwickCambridge OesophagoGastric Centre, Cambridge, UK.
Arnulf HoelscherAgaplesion Markus Krankenhaus, Frankfurt, Germany.
Wayne HofstetterMD Anderson Cancer Center, Houston, TX.
Blair JobeAllegheny Health System, Pittsburg, PA.
Yuko KitagawaKeio University, Tokyo, Japan.
Simon LawQueen Mary Hospital, Hong Kong, China.
Christophe MarietteUniversity Hospital of Lille, Lille, France.
Nick MaynardOxford OesophagoGastric Centre, Oxford, UK.
Christopher R MorseMassachusetts General Hospital, Boston, MA.
Philippe NafteuxKatholieke Universiteit Leuven, Leuven, Belgium.
Manuel PeraHospital Universitario del Mar, Barcelona, Spain.
C S PrameshTata Memorial Hospital, Mumbai, Maharashtra, India.
Sonia PuigQueen Elizabeth Hospital, Birmingham, UK.
John V ReynoldsTrinity College Dublin, Dublin, Ireland.
Wolfgang SchroederUniversity of Cologne, Cologne, Germany.
Mark SmithersThe University of Queensland, Brisbane, Queensland, Australia.
B P L WijnhovenErasmus Medical Center, Rotterdam, The Netherlands.
Virginia Mason Medical Center · USMichigan Medicine · USToronto General Hospital · CAUniversity of Birmingham · GBAcademic Medical Center · NLKeio University · JPMassachusetts General Hospital · USQueen Mary Hospital · CNSt Thomas' Hospital · GBTata Memorial Hospital · INThe University of Texas MD Anderson Cancer Center · USTrinity College Dublin · IEUniversidade de São Paulo · BRUniversity of Cologne · DEUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUtilizing a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esophagectomy. SUMMARY OF BACKGROUND DATA: Outcome reporting in oncologic surgery has suffered from the lack of a standardized system for reporting operative results particularly complications. This is particularly the case for esophagectomy affecting the accuracy and relevance of international outcome assessments, clinical trial results, and quality improvement projects.

methodsThe Esophageal Complications Consensus Group (ECCG) involving 24 high-volume esophageal surgical centers in 14 countries developed a standardized platform for recording complications and quality measures associated with esophagectomy. Using a secure online database (ESODATA.org), ECCG centers prospectively recorded data on all resections according to the ECCG platform from these centers over a 2-year period.

resultsBetween January 2015 and December 2016, 2704 resections were entered into the database. All demographic and follow-up data fields were 100% complete. The majority of operations were for cancer (95.6%) and typically located in the distal esophagus (56.2%). Some 1192 patients received neoadjuvant chemoradiation (46.1%) and 763 neoadjuvant chemotherapy (29.5%). Surgical approach involved open procedures in 52.1% and minimally invasive operations in 47.9%. Chest anastomoses were done most commonly (60.7%) and R0 resections were accomplished in 93.4% of patients. The overall incidence of complications was 59% with the most common individual complications being pneumonia (14.6%) and atrial dysrhythmia (14.5%). Anastomotic leak, conduit necrosis, chyle leaks, recurrent nerve injury occurred in 11.4%, 1.3%, 4.7%, and 4.2% of cases, respectively. Clavien-Dindo complications ≥ IIIb occurred in 17.2% of patients. Readmissions occurred in 11.2% of cases and 30- and 90-day mortality was 2.4% and 4.5%, respectively.

conclusionStandardized methods provide contemporary international benchmarks for reporting outcomes after esophagectomy.

Indexed as

BenchmarkingAdultAgedAged, 80 and overEsophageal NeoplasmsEsophagectomyFemaleHumansMaleMiddle AgedPostoperative ComplicationsTreatment Outcome

Identifiers

PMID29206677
OpenAlexW2775574711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.