Evidence map›Paper›PMID 29206488›Full record

ArticleExperimental lung research

Structural and functional evidence for the scaffolding effect of alveolar blood vessels.

Barry C Gibney, Willi L Wagner, Alexandra B Ysasi, Janeil M Belle, Akira Tsuda, Maximilian Ackermann, Steven J Mentzer

Open access · greenAbstract read
In one paragraph

Article in Experimental lung research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Barry C Gibneya Laboratory of Adaptive and Regenerative Biology , Brigham & Women's Hospital, Harvard, Medical School , Boston , MA.
Willi L Wagnerb Institute of Functional and Clinical Anatomy , University Medical Center of the Johannes Gutenberg-University , Mainz , Germany.
Alexandra B Ysasia Laboratory of Adaptive and Regenerative Biology , Brigham & Women's Hospital, Harvard, Medical School , Boston , MA.
Janeil M Bellea Laboratory of Adaptive and Regenerative Biology , Brigham & Women's Hospital, Harvard, Medical School , Boston , MA.
Akira Tsudac Molecular and Integrative Physiological Sciences , Harvard School of Public Health , Boston , MA.
Maximilian Ackermannb Institute of Functional and Clinical Anatomy , University Medical Center of the Johannes Gutenberg-University , Mainz , Germany.
Steven J Mentzera Laboratory of Adaptive and Regenerative Biology , Brigham & Women's Hospital, Harvard, Medical School , Boston , MA.
Brigham and Women's Hospital · USHarvard University · USJohannes Gutenberg University Mainz · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
ADVANCED TRAINING IN SURGICAL ONCOLOGYT32CA009535 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUENO, RAPHAEL · 1985 to 2015
$3.5M
Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive AngiogenesisR01HL094567 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MENTZER, STEVEN · 2009 to 2016
$3.2M
Physiology of Systemic and Pulmonary MicroangiectasiasR01HL075426 · NHLBI · DANA-FARBER CANCER INSTITUTE · PI MENTZER, STEVEN · 2003 to 2006
$1.4M
NCI NIH HHS T32 CA009535NHLBI NIH HHS R01 HL075426NHLBI NIH HHS R01 HL094567NHLBI NIH HHS T32 HL007734
6 · The paper itself

Abstract

A contribution of pulmonary blood distension to alveolar opening was first proposed more than 100 years ago. To investigate the contribution of blood distension to lung mechanics, we studied control mice (normal perfusion), mice after exsanguination (absent perfusion) and mice after varying degrees of parenchymal resection (supra-normal perfusion). On inflation, mean tracheal pressures were higher in the bloodless mouse (4.0 ± 2.5 cm H

Indexed as

Airway ResistanceAnimalsBlood VesselsLungMicePositive-Pressure RespirationPulmonary AlveoliRespiratory Mechanicsblood perfusioncapillariescorrosion castinglung mechanicsscanning electron microscopy

Identifiers

PMID29206488
PMCPMC6134835
OpenAlexW2773309850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.