Evidence map›Paper›PMID 29206325›Full record

ReviewHead & neck2018

Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis.

Alvaro Sanabria, Luiz P Kowalski, Jatin P Shah, Iain J Nixon, Peter Angelos, Michelle D Williams, Alessandra Rinaldo, Alfio Ferlito

Abstract readReview
In one paragraph

Review in Head & neck, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. [Improving Postgraduate Medical Training In Germany: A Proposal].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2024
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  19. Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alvaro SanabriaDepartment of Surgery, School of Medicine, Universidad de Antioquia, Clinica Vida/Instituto de Cancerología Las Americas, Medellin, Colombia, South America.
Luiz P KowalskiDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
Jatin P ShahDepartment of Head and Neck Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Iain J NixonEdinburgh University, Edinburgh, Scotland.ORCID 0000-0002-8919-8783
Peter AngelosDepartment of Surgery, University of Chicago, Chicago, Illinois.
Michelle D WilliamsDepartment of Pathology, Division of Pathology/Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Alessandra RinaldoUniversity of Udine School of Medicine, Udine, Italy.
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

There is an increasing incidence of well-differentiated thyroid cancer worldwide. Much of the increase is secondary to increased detection of small, low-risk tumors, with questionable clinical significance. This review addresses the factors that contribute to the increasing incidence and considers environmental, and patient-based and clinician-led influences. Articles addressing the causes of the increased incidence were critically reviewed. A complex interplay of environmental, medical, and social pressures has resulted in increased awareness of the thyroid disease risk, increased screening of thyroid cancers, and increased diagnosis of thyroid cancers. Although there is evidence to suggest that the true disease incidence may be changing slightly, most of the increase is related to factors that promote early diagnosis of low-risk lesions, which is resulting in a significant phenomenon of overdiagnosis. An improved understanding of these pressures at a global level will enable healthcare policymakers to react appropriately to this challenge in the future.

Indexed as

Early Detection of CancerFemaleHumansIncidenceMaleMedical OveruseRisk AssessmentThyroid NeoplasmsUnited Statesincidencemedical overuseoverdiagnosisscreeningthyroid neoplasm

Identifiers

PMID29206325
PMCPMC5849517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.