ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2018
Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re-Visiting the "Gene-Battery" Model.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Gene regulatory innovations from transposable elements in primate cerebellum development.Nature communications · 2026Article
- Transposable elements in hematopoietic stem cells upon aging and myeloid malignancies.Mobile DNA · 2026Review
- Liver-specific enhancers evolved from independent episodes of MITE domestication in Xenopus tropicalis.Mobile DNA · 2025Article
- Technology to the rescue: how to uncover the role of transposable elements in preimplantation development.Biochemical Society transactions · 2024Review
- Towards targeting transposable elements for cancer therapy.Nature reviews. Cancer · 2024Review
- Primate-specific transposable elements shape transcriptional networks during human development.Nature communications · 2022Article
- NF-κB signaling controls H3K9me3 levels at intronic LINE-1 and hematopoietic stem cell genes in cis.The Journal of experimental medicine · 2022Article
- Epigenomic analysis reveals prevalent contribution of transposable elements toGenome research · 2022Article
- Caenorhabditis elegans transposable elements harbor diverse transcription factor DNA-binding sites.G3 (Bethesda, Md.) · 2022Article
- Segregating Complete Tf2 Elements Are Largely Neutral in Fission Yeast.Genome biology and evolution · 2021Article
- The large bat Helitron DNA transposase forms a compact monomeric assembly that buries and protects its covalently bound 5'-transposon end.Molecular cell · 2021Article
- Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.Genome biology · 2021Article
- Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation.Nature communications · 2021Article
- Expression Quantitative Trait Loci (eQTLs) Associated with Retrotransposons Demonstrate their Modulatory Effect on the Transcriptome.International journal of molecular sciences · 2021Article
- Tissue-specific usage of transposable element-derived promoters in mouse development.Genome biology · 2020Article
- Transposable elements as a potent source of diversePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Contribution of unfixed transposable element insertions to human regulatory variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Co-opted transposons help perpetuate conserved higher-order chromosomal structures.Genome biology · 2020Article
- Jump around: transposons in and out of the laboratory.F1000Research · 2020Review
- Diversification of theeLife · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Transposable elements (TEs) are no longer considered to be "junk" DNA. Here, we review how TEs can impact gene regulation systematically. TEs encode various regulatory elements that enables them to regulate gene expression. RJ Britten and EH Davidson hypothesized that TEs can integrate the function of various transcriptional regulators into gene regulatory networks. Uniquely TEs can deposit regulatory sites across the genome when they transpose, and thereby bring multiple genes under control of the same regulatory logic. Several studies together have robustly established that TEs participate in embryonic development and oncogenesis. We discuss the regulatory characteristics of TEs in context of evolution to understand the extent of their impact on gene networks. Understanding these features of TEs is central to future investigations of TEs in cellular processes and phenotypic presentations, which are applicable to development and disease studies. We re-visit the Britten-Davidson "gene-battery" model and understand the genetic and transcriptional impact of TEs in innovating gene regulatory networks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.