ArticlePloS one2017
Site-level progression of periodontal disease during a follow-up period.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis on the adjunctive use of host immune modulators in non-surgical periodontal treatment in healthy and systemically compromised patients.Scientific reports · 2021Pooled it
- Relationship between herpesviruses and periodontal disease progression.Journal of clinical periodontology · 2020Trial
- Evaluating Factors Influencing Periodontal Bone Loss Using Cone Beam Computed Tomography: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis.Nature communications · 2024Article
- The Association between Salivary Metabolites and Gingival Bleeding Score in Healthy Subjects: A Pilot Study.International journal of molecular sciences · 2024Article
- Prevalence and Severity of Circumferential Alveolar Bone Loss Using CBCT Images: A Retrospective Study of 20,620 Surfaces of 5155 Teeth.Diagnostics (Basel, Switzerland) · 2024Article
- The Relationship Between Mental Health and Periodontal Disease: Insights from NHANES Data.F1000Research · 2024Article
- Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment-An Open Label Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- The Chairside Periodontal Diagnostic Toolkit: Past, Present, and Future.Diagnostics (Basel, Switzerland) · 2021Review
- Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis.Journal of clinical medicine · 2021Article
- Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination.Journal of clinical medicine · 2021Article
- Comparative Effects of E-Cigarette Aerosol on Periodontium of Periodontitis Patients.Frontiers in oral health · 2021Article
- Optimal Examination Sites for Periodontal Disease Evaluation: Applying the Item Response Theory Graded Response Model.Journal of clinical medicine · 2020Article
- Effect of Mucosal Brushing on the Serum Levels of C-Reactive Protein for Patients Hospitalized with Acute Symptoms.Medicina (Kaunas, Lithuania) · 2020Article
- Tooth-Level Analysis of Dental Caries in Primary Dentition in Myanmar Children.International journal of environmental research and public health · 2020Article
- BAREB: A Bayesian repulsive biclustering model for periodontal data.Statistics in medicine · 2020Article
- Prevalence of periodontitis and alveolar bone loss in a patient population at Harvard School of Dental Medicine.BMC oral health · 2019Article
- To P or not to P, is that the question? Rethinking experimental design and data analysis to improve biological significance beyond the statistical significance.Journal of applied oral science : revista FOB · 2019Article
- Long-term assessment of periodontal disease progression after surgical or non-surgical treatment: a systematic review.Journal of periodontal & implant science · 2019Review
- Factors That Affect Oral Care Outcomes for Institutionalized Elderly.International journal of dentistry · 2018Article
Corrections and comments
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Authors and funding
38 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is assessed and its progression is determined via observations on a site-by-site basis. Periodontal data are complex and structured in multiple levels; thus, applying a summary statistical approach (i.e., the mean) for site-level evaluations results in loss of information. Previous studies have shown the availability of mixed effects modeling. However, clinically beneficial information on the progression of periodontal disease during the follow-up period is not available. We conducted a multicenter prospective cohort study. Using mixed effects modeling, we analyzed 18,834 sites distributed on 3,139 teeth in 124 patients, and data were collected 5 times over a 24-month follow-up period. The change in the clinical attachment level (CAL) was used as the outcome variable. The CAL at baseline was an important determinant of the CAL changes, which varied widely according to the tooth surface. The salivary levels of periodontal pathogens, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, were affected by CAL progression. "Linear"- and "burst"-type patterns of CAL progression occurred simultaneously within the same patient. More than half of the teeth that presented burst-type progression sites also presented linear-type progression sites, and most of the progressions were of the linear type. Maxillary premolars and anterior teeth tended to show burst-type progression. The parameters identified in this study may guide practitioners in determining the type and extent of treatment needed at the site and patient levels. In addition, these results show that prior hypotheses concerning "burst" and "linear" theories are not valid.
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