Evidence map›Paper›PMID 29206084›Full record

ArticlePulmonary circulation

Identity crisis in pulmonary arterial hypertension.

G Ruffenach, S Bonnet, S Rousseaux, S Khochbin, S Provencher, F Perros

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. The hallmarks of severe pulmonary arterial hypertension: the cancer hypothesis-ten years later.American journal of physiology. Lung cellular and molecular physiology · 2020
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

G Ruffenach1 Groupe de recherche en hypertension pulmonaire et biologie vasculaire, 55973 Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, QC, Canada.
S Bonnet1 Groupe de recherche en hypertension pulmonaire et biologie vasculaire, 55973 Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, QC, Canada.
S Rousseaux2 55608 CNRS UMR5309, Inserm U1209, Université de Grenobles Alpes, Institut Albert Bonniot, Grenoble, France.
S Khochbin2 55608 CNRS UMR5309, Inserm U1209, Université de Grenobles Alpes, Institut Albert Bonniot, Grenoble, France.
S Provencher1 Groupe de recherche en hypertension pulmonaire et biologie vasculaire, 55973 Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, QC, Canada.
F Perros1 Groupe de recherche en hypertension pulmonaire et biologie vasculaire, 55973 Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell "identity crisis." Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.

Indexed as

cancer hallmarksDarwinian evolutionpulmonary hypertensiontissues-specific gene

Identifiers

PMID29206084
PMCPMC5731718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.