ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2018
Cerebral White Matter Maturation Patterns in Preterm Infants: An MRI T2 Relaxation Anisotropy and Diffusion Tensor Imaging Study.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Unifying orientation-dependent relaxation and diffusion around axonal fibers in DTI: characterizing fiber-tract-specific anisotropic RBrain structure & function · 2026Article
- Review
- SEPoolConvNeXt: A Deep Learning Framework for Automated Classification of Neonatal Brain Development Using T1- and T2-Weighted MRI.Journal of clinical medicine · 2025Article
- Imaging biomarkers for detection and longitudinal monitoring of ventricular abnormalities from birth to childhood.World journal of radiology · 2025Review
- Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants.Pediatric radiology · 2024Article
- Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review.Clinical and experimental pediatrics · 2024Article
- Predicting 2-year neurodevelopmental outcomes in preterm infants using multimodal structural brain magnetic resonance imaging with local connectivity.Scientific reports · 2024Article
- Multi-view fusion of diffusion MRI microstructural models: a preterm birth study.Frontiers in neuroscience · 2024Article
- Phase-shifted transverse relaxation orientation dependences in human brain white matter.NMR in biomedicine · 2023Article
- Article
- Early structural connectivity within the sensorimotor network: Deviations related to prematurity and association to neurodevelopmental outcome.Frontiers in neuroscience · 2022Article
- Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Tract-Specific Relationships Between Cerebrospinal Fluid Biomarkers and Periventricular White Matter in Posthemorrhagic Hydrocephalus of Prematurity.Neurosurgery · 2021Article
- Multi-Channel 4D Parametrized Atlas of Macro- and Microstructural Neonatal Brain Development.Frontiers in neuroscience · 2021Article
- Quantitative assessment of myelination patterns in preterm neonates using T2-weighted MRI.Scientific reports · 2019Article
- Altered neonatal white and gray matter microstructure is associated with neurodevelopmental impairments in very preterm infants with high-grade brain injury.Pediatric research · 2019Article
- The Role of Diffusion Tensor Imaging in Detecting Hippocampal Injury Following Neonatal Hypoxic-Ischemic Encephalopathy.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019Article
- Nurturing the preterm infant brain: leveraging neuroplasticity to improve neurobehavioral outcomes.Pediatric research · 2019Review
- White Matter Plasticity in Reading-Related Pathways Differs in Children Born Preterm and at Term: A Longitudinal Analysis.Frontiers in human neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposePreterm birth is associated with worse neurodevelopmental outcome, but brain maturation in preterm infants is poorly characterized with standard methods. We evaluated white matter (WM) of infant brains at term-equivalent age, as a function of gestational age at birth, using multimodal magnetic resonance imaging (MRI).
methodsInfants born very preterm (<32 weeks gestation) and late preterm (33-36 weeks gestation) were scanned at 3 T at term-equivalent age using diffusion tensor imaging (DTI) and T2 relaxometry. MRI data were analyzed using tract-based spatial statistics, and anisotropy of T2 relaxation was also determined. Principal component analysis and linear discriminant analysis were applied to seek the variables best distinguishing very preterm and late preterm groups.
resultsAcross widespread regions of WM, T2 is longer in very preterm infants than in late preterm ones. These effects are more prevalent in regions of WM that myelinate earlier and faster. Similar effects are obtained from DTI, showing that fractional anisotropy (FA) is lower and radial diffusivity higher in the very preterm group, with a bias toward earlier myelinating regions. Discriminant analysis shows high sensitivity and specificity of combined T2 relaxometry and DTI for the detection of a distinct WM development pathway in very preterm infants. T2 relaxation is anisotropic, depending on the angle between WM fiber and magnetic field, and this effect is modulated by FA.
conclusionsCombined T2 relaxometry and DTI characterizes specific patterns of retarded WM maturation, at term equivalent age, in infants born very preterm relative to late preterm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.