Evidence map›Paper›PMID 29205554›Full record

ArticleMolecular microbiology2018

VapA of Rhodococcus equi binds phosphatidic acid.

Lindsay M Wright, Emily M Carpinone, Terry L Bennett, Mary K Hondalus, Vincent J Starai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB.Acta crystallographica. Section F, Structural biology communications · 2021
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsay M WrightDepartment of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Emily M CarpinoneDepartment of Microbiology, University of Georgia, Athens, GA 30602, USA.
Terry L BennettDepartment of Microbiology, University of Georgia, Athens, GA 30602, USA.
Mary K HondalusDepartment of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Vincent J StaraiDepartment of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-2415-412X

Funding

Bacterial inhibitors of eukaryotic membrane fusionR01AI100913 · NIAID · UNIVERSITY OF GEORGIA · PI STARAI, VINCENT JOSEPH · 2013 to 2017
$1.7M
NIAID NIH HHS R01 AI100913
6 · The paper itself

Abstract

Rhodococcus equi is a multihost, facultative intracellular bacterial pathogen that primarily causes pneumonia in foals less than six months in age and immunocompromised people. Previous studies determined that the major virulence determinant of R. equi is the surface bound virulence associated protein A (VapA). The presence of VapA inhibits the maturation of R. equi-containing phagosomes and promotes intracellular bacterial survival, as determined by the inability of vapA deletion mutants to replicate in host macrophages. While the mechanism of action of VapA remains elusive, we show that soluble recombinant VapA

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialLipidsMacrophagesPhagosomesPhosphatidic AcidsRhodococcus equiStaphylococcal Protein AVirulenceVirulence FactorsBacterial ProteinsLipidsPhosphatidic AcidsStaphylococcal Protein AVapA protein, Rhodococcus equiVirulence Factors

Identifiers

PMID29205554
PMCPMC5777868

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.