ArticleAlcoholism, clinical and experimental research2018
Ovarian Hormones Contribute to High Levels of Binge-Like Drinking by Female Mice.
Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies.Addiction biology · 2025Pooled it
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Heightened sensitivity to the disinhibiting effect of alcohol in women during the late follicular phase of the menstrual cycle.Experimental and clinical psychopharmacology · 2023Trial
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Sex differences in alcohol-induced transcriptional changes in the nucleus accumbens depend on sex chromosome complement and gonadal type.Research square · 2026Article
- Individual differences in ethanol drinking meal structure are shaped by social environments.bioRxiv : the preprint server for biology · 2026Article
- Regulation of Chromatin Acetylation by Alcohol: Dependence on Sex, Brain Region, and Mode of Exposure.Genes · 2026Review
- Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence.Psychopharmacology · 2026Article
- Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability.Biological psychiatry global open science · 2026Article
- The effects of adolescent social isolation and group housing on adolescent binge drinking in mice.PloS one · 2026Article
- Contributions of testosterone to excessive alcohol drinking in males: Potential role for interactions with the HPA axis.Alcohol (Fayetteville, N.Y.) · 2025Review
- The role of neuroactive steroids in psychiatric and neurological disorders: Neurobiology and therapeutic perspectives.Neuroscience and biobehavioral reviews · 2025Review
- Sex differences in acute tolerance to the objective and subjective effects of alcohol.Pharmacology, biochemistry, and behavior · 2025Article
- Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus.Neuropharmacology · 2025Article
- Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward.Biology of sex differences · 2025Article
- Juvenile hormone regulates the maturation of sexually dimorphic naive ethanol olfactory preference inRoyal Society open science · 2025Article
- Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice.bioRxiv : the preprint server for biology · 2025Article
- KAlcohol (Fayetteville, N.Y.) · 2025Article
- Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats.Scientific reports · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecently, the incidence of binge drinking by women has increased. Binge drinking is detrimental to women's health, yet the biological mechanisms that promote excessive drinking by women are not well understood. One method of assessing binge-like ethanol (EtOH) consumption in mice is the drinking in the dark (DID) test, in which mice drink sufficient EtOH to achieve intoxication. In this study, we directly compared male, female, and ovariectomized (OVX) mice for DID and tested whether 17β-estradiol (E2) contributes to DID. We also measured whether DID varies throughout the estrous cycle and whether repeated intermittent DID impacts the estrous cycle.
methodsMale, female, and OVX C57BL/6J mice were tested for DID for 2 hours per day on days 1 to 3 and for 4 hours on day 4 using a single bottle containing 20% EtOH. To measure the effects of E2 on DID, OVX mice were treated with estradiol benzoate (EB) or vehicle daily starting 2 weeks prior to the drinking test and throughout the DID procedure. In a separate group of experiments, EtOH consumption and estrous cycle phase were measured in freely cycling mice that were drinking EtOH or water 5 days per week for 2 or 6 weeks.
resultsFemale mice consumed more EtOH than male and OVX mice. Treatment with EB increased EtOH consumption by OVX mice compared with vehicle-treated controls. However, EtOH intake did not vary across the estrous cycle, nor did long-term DID alter the estrous cycle.
conclusionsThese results demonstrate that ovarian hormones, specifically E2, contribute to increased EtOH consumption by female mice in the DID test. Although ovarian hormones contribute to this behavior, EtOH consumption is not affected by estrous cycle phase in freely cycling mice. This study provides a framework for understanding the factors that contribute to binge drinking in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.