ArticleJournal of Zhejiang University. Science. B
Polymorphisms of the IGF1 gene and their association with growth traits, serum concentration and expression rate of IGF1 and IGF1R in buffalo.
Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic Diversity and Candidate Selection Signatures in Hungarian and Romanian Carpathian Water Buffalo Inferred from Cross-Species SNP-Array Genotyping.Animals : an open access journal from MDPI · 2026Article
- Effect of zinc oxide or selenium nanoparticles on body weight, growth related genes and physiology in Baladi goats.Scientific reports · 2025Article
- Correlation and regression analysis of GH and IGF-1 genes in Liaoning cashmere goats with body size and other production performance.Journal, genetic engineering & biotechnology · 2024Article
- Association of insulin-like growth factor 1 (IGF1) gene polymorphism with the reproductive performance of three dual-purpose chicken breeds.Translational animal science · 2021Article
- Polymorphisms of the PRLR Gene and Their Association with Milk Production Traits in Egyptian Buffaloes.Animals : an open access journal from MDPI · 2021Article
- Association of GHR Polymorphisms with Milk Production in Buffaloes.Animals : an open access journal from MDPI · 2020Article
- Article
- Single nucleotide polymorphisms in the growth hormone receptor gene andVeterinary world · 2020Article
- Effect of insulin-like growth factor 1 gene on growth traits of Kejobong goat and its growth analysis.Veterinary world · 2020Article
- IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population.Medicine · 2019Article
- Association between a novel G94A single nucleotide polymorphism inJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insulin-like growth factor 1 (IGF1) gene is a member of the group of somatotropin axis genes that play a significant role in cell proliferation and growth of muscles. Here, we searched for polymorphisms in buffalo IGF1 and found two novel single nucleotide polymorphisms (SNPs), G64A and G280A, in the noncoding sequences of exon 1 and exon 4, respectively. Statistical analysis of different genotypes showed that the individuals with GG genotypes had significantly (P<0.05) higher body weight (BW) and average daily gain (ADG) than those with other genotypes at ages of 3-6 months in G64A SNP and 6-9 months in G280A SNP. The combined genotypes of these two SNPs produced three haplotypes, GG/GG, AG/AG, and AA/AA, which were significantly associated (P<0.0001) with BW and ADG at an age from 3 to 12 months. Buffaloes with the homozygous GG/GG haplotype showed higher growth performance than other buffaloes. The two SNPs were correlated with mRNA levels of IGF1 and IGF1 receptor (IGF1R) in semitendinosus muscle as well as with the serum concentration level of IGF1. Also, buffaloes with GG/GG haplotype showed higher mRNA and serum concentration levels. The data revealed that these two SNPs could be valuable genetic markers for selection of Egyptian buffaloes for better performance in the population.
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