Evidence map›Paper›PMID 29204924›Full record

Trial reportDrug delivery and translational research2018

Efficacy of a bleomycin microneedle patch for the treatment of warts.

Ha Ryeong Ryu, Hye-Rin Jeong, Hye-Seung Seon-Woo, Jung Soo Kim, Seul Ki Lee, Hee Joo Kim, Jin Ok Baek, Jung-Hwan Park, Joo Young Roh

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Microneedles: Selected Applications for Pediatrics.Children (Basel, Switzerland) · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Patchless administration of canine influenza vaccine on dog's ear using insertion-responsive microneedles (IRMN) without removal of hair and its in vivo efficacy evaluation.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2020
    Article
  16. Microneedle Coating Methods: A Review with a Perspective.The Journal of pharmacology and experimental therapeutics · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ha Ryeong RyuDepartment of Dermatology, Gachon University Gil Medical Center, Incheon, South Korea.
Hye-Rin JeongDepartment of BioNano Technology and Gacheon BioNano Research Institute, Gachon University, Seongnam, South Korea.
Hye-Seung Seon-WooDepartment of BioNano Technology and Gacheon BioNano Research Institute, Gachon University, Seongnam, South Korea.
Jung Soo KimDepartment of Dermatology, Gachon University Gil Medical Center, Incheon, South Korea.
Seul Ki LeeDepartment of Dermatology, Gachon University Gil Medical Center, Incheon, South Korea.
Hee Joo KimDepartment of Dermatology, Gachon University Gil Medical Center, Incheon, South Korea.
Jin Ok BaekDepartment of Dermatology, Gachon University Gil Medical Center, Incheon, South Korea.
Jung-Hwan ParkDepartment of BioNano Technology and Gacheon BioNano Research Institute, Gachon University, Seongnam, South Korea. pa90201@gachon.ac.kr.
Joo Young RohDepartment of Dermatology, Gachon University Gil Medical Center, Incheon, South Korea. jyroh1@gilhospital.com.
Gachon University Gil Medical Center · KRGachon University · KR

Funding

Korea Health Technology 2013-47MOTIE 10067809
6 · The paper itself

Abstract

Warts are a common skin disease caused by infection of the human papilloma virus. Most treatments involving physical destruction of the infected cells, such as cryotherapy and electrocautery, are limited by intense pain, failure, or recurrences. Our aim was to compare the therapeutic effects of a newly developed bleomycin microneedle patch with cryotherapy in the treatment of warts. Forty-two patients with more than two wart lesions were included in the study. The two treatment modalities were randomly applied to different warts on each patient. Treatment efficacy was assessed using the Physician's Global Assessment (PGA) and the Patient's Global Assessment (PaGA). Mean PGA and PaGA scores were not significantly different between cryotherapy and bleomycin microneedle patch treatment. It was also determined that the mean size of all the warts treated with either modality shrank about equally at weeks 8 and 16 after initial treatment. Thus, treatment efficacy of the bleomycin microneedle patch was comparable to that of conventional cryotherapy. According to a visual analogue scale of pain, bleomycin microneedle patch treatment was significantly less painful than cryotherapy (p < .0001). In addition, use of the bleomycin microneedle patch was more tolerable for patients who were reluctant to receive the painful treatment. Thus, the bleomycin microneedle patch can be an effective, convenient, and innovative treatment modality for warts.

Indexed as

AdolescentAdultAntiviral AgentsBleomycinChildChild, PreschoolCryotherapyFemaleHumansMaleMicroinjectionsMiddle AgedNeedlesPainTransdermal PatchTreatment OutcomeAntiviral AgentsBleomycinBleomycin microneedle patchCryotherapyEfficacyPainTreatment of warts

Identifiers

PMID29204924
OpenAlexW2771926393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.