ArticleEuropean biophysics journal : EBJ2018
Spatial scales of living cells and their energetic and informational capacity.
Article in European biophysics journal : EBJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Folding-unfolding asymmetry and aRoyal Society open science · 2023Article
- Topological bio-scaling analysis as a universal measure of protein folding.Royal Society open science · 2022Article
- The Effect of the Protein Synthesis Entropy Reduction on the Cell Size Regulation and Division Size of Unicellular Organisms.Entropy (Basel, Switzerland) · 2022Article
- The optimal size of protocells from simple entropic considerations.European biophysics journal : EBJ · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical (thermodynamic and kinetic), chemical, and biological reasoning restrict the spatial dimensions of living cells (prokaryotic and eukaryotic) and confine them to between 1 and 100 µm. Cells should necessarily be macroscopic, dissipative objects, resisting thermal fluctuations and providing sufficient informational capacity. The upper limit of the spatial dimensions of cells is supplied by their ability to withstand gravity and inertia forces under reasonable deformations. The upper limit of cell dimensions is also governed by the hierarchy of characteristic time scales, inherent for mass and heat transport. For micron-scaled cells, the "traffic time" (namely a typical time necessary for the migration of one enzyme to another) is on the order of magnitude of a millisecond, which coincides with the characteristic time scale of a single round of the catalytic enzyme cycle. The macroscopic dimensions of living cells (seen as dissipative systems) and the hierarchy of time scales of the mass transfer processes vs. those inherent for heat transport and viscous dissipation give rise to the irreversibility of biological processes.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.