ArticleInflammation2018
Anti-inflammatory Effects of Rosmarinic Acid in Lipopolysaccharide-Induced Mastitis in Mice.
Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
47 citing papers in PubMed, 79 citations in OpenAlex.
- Antibacterial Activity of Rosmarinic Acid AgainstAnimals : an open access journal from MDPI · 2026Article
- Caffeic Acid Counteracts LPS-Induced Inflammatory Damage in Yak Mammary Epithelial Cells Associated with NF-κB-Mediated Autophagy Regulation.Animals : an open access journal from MDPI · 2026Article
- Biological functions and applications of rosemary extracts in animal production.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- LC-MS Analysis of the Polyphenolic Composition and Assessment of the Antioxidant, Anti-Inflammatory and Cardioprotective Activities ofPlants (Basel, Switzerland) · 2025Article
- Rosmarinic Acid Attenuates Paraquat-Induced Lung Injury by Suppressing Inflammatory Responses in Mice.Reports of biochemistry & molecular biology · 2025Article
- Network Pharmacology and Molecular Docking: Exploring the Mechanism of Peppermint in Mastitis Prevention and Treatment in Dairy Cows.Veterinary sciences · 2025Article
- LPS Disrupts Endometrial Receptivity by Inhibiting STAT1 Phosphorylation in Sheep.International journal of molecular sciences · 2024Article
- Rosmarinic acid-mediated downregulation of RIG-I and p62 in microglia confers resistance to Japanese encephalitis virus-induced inflammation.BMC veterinary research · 2024Article
- Ultra-Performance Liquid Chromatography and Mass Spectrometry Characterization, and Antioxidant, Protective, and Anti-Inflammatory Activity, of the Polyphenolic Fraction fromMolecules (Basel, Switzerland) · 2024Article
- Bioactive Compounds and Probiotics Mitigate Mastitis by Targeting NF-κB Signaling Pathway.Biomolecules · 2024Review
- Versatile CYP98A enzymes catalyse meta-hydroxylation reveals diversity of salvianolic acids biosynthesis.Plant biotechnology journal · 2024Article
- Phenolic acids from medicinal and edible homologous plants: a potential anti-inflammatory agent for inflammatory diseases.Frontiers in immunology · 2024Review
- Article
- Integrated analysis of inflammatory mRNAs, miRNAs, and lncRNAs elucidates the molecular interactome behind bovine mastitis.Scientific reports · 2023Article
- Exploring the Traditional Uses ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Effect ofNutrients · 2023Article
- Phenolic Content, Antioxidant, Antibacterial, Antihyperglycemic, and α-Amylase Inhibitory Activities of Aqueous Extract ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Phytochemicals in the treatment of inflammation-associated diseases: the journey from preclinical trials to clinical practice.Frontiers in pharmacology · 2023Review
- Article
- Journey of Rosmarinic Acid as Biomedicine to Nano-Biomedicine for Treating Cancer: Current Strategies and Future Perspectives.Pharmaceutics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Rosmarinic acid (RA), a type of food additives mainly extracted from rosemary, has been reported to possess anti-inflammatory activities in some previous studies. However, the effects of RA on lipopolysaccharide (LPS)-induced mastitis have not been reported. Here, we investigated the anti-inflammatory effects of RA on LPS-induced mastitis in mice and elucidated the potential mechanisms in mouse mammary epithelial cells (mMECs). RA treatment significantly ameliorated the mammary structural damage, and reduced the activity of myeloperoxidase. ELISA and qPCR results indicated that RA dose-dependently decreased the expression of TNF-α, IL-1β, and IL-6 both in tissues and mMECs. Furthermore, RA remarkably suppressed the protein levels of TLR4, MyD88, IRAK1, TRAF6, and p-IKKβ. In addition, RA was also found to inhibit LPS-induced NF-κB signaling pathway activation. These results suggest that RA effectively attenuates LPS-induced mastitis by inhibiting the TLR4/MyD88/NF-κB signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.