Evidence map›Paper›PMID 29204573›Full record

ArticleWorld journal of otorhinolaryngology - head and neck surgery2017

Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B.

Do-Yeon Cho, Kyle J Hoffman, Gobind S Gill, Dong-Jin Lim, Daniel Skinner, Calvin Mackey, Steven M Rowe, Bradford A Woodworth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of otorhinolaryngology - head and neck surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Do-Yeon ChoDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Kyle J HoffmanDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Gobind S GillDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Dong-Jin LimDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Daniel SkinnerDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Calvin MackeyDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Steven M RoweGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Bradford A WoodworthDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Ivacaftor for Acquired CFTR Dysfunction in Chronic RhinosinusitisR01HL133006 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2016 to 2020
$1.7M
NHLBI NIH HHS R01 HL133006
6 · The paper itself

Abstract

objectiveAmphotericin B (AMB), a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) for the treatment of fungal infections has been recently developed to provide greater protection from AMB toxicity than current, clinically approved lipid-based formulations. The objective of the current study was to evaluate the safety and potency of ND-AMB for sinonasal delivery using an

methodsHuman sinonasal tissue was harvested during endoscopic sinus surgery and grown at air-liquid interface until well-differentiated. Cultures were exposed to ND-AMB vs AMB and changes in K

resultsUssing chamber studies revealed K

conclusionsData from the present study suggests ND-AMB protects human nasal epithelia membranes from AMB toxicity by protecting against apical cell K

Indexed as

AmphotericinChronic rhinosinusitisCiliary beat frequencyDrug deliveryMucociliary clearanceSinus epitheliumSinusitisTransepithelial ion transport

Identifiers

PMID29204573
PMCPMC5683641

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.