Evidence map›Paper›PMID 29204537›Full record

ReviewWorld journal of otorhinolaryngology - head and neck surgery2015

Olfactory dysfunction and its measurement in the clinic.

Richard L Doty

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of otorhinolaryngology - head and neck surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710394 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy of Bimodal Visual-Olfactory Training in Participants With COVID-19 Resultant Hyposmia or Anosmia Using Participant-Preferred Scents

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2022Enrolled240ConditionsAnosmia, Covid19, Ageusia, HyposmiaArmsSmell Training
NCT05184192 phase2completednot on this mapstarted 2022, after this paper: background citation

Efficacy of Gabapentin for Post-Covid-19 Olfactory Dysfunction

TypeinterventionalSponsorWashington University School of MedicineRan2022 to 2023Enrolled68ConditionsCOVID-19, Olfactory Disorder, Anosmia, HyposmiaArmsGabapentin gelatin capsules 300mg, Placebo
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. The efficacy of olfactory training in improving olfactory function: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment.Journal of neurology, neurosurgery, and psychiatry · 2017
    Pooled it
  6. Diagnostics of olfactory dysfunction in Parkinson's disease - a literature overview and case series.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026
    Review
  7. Review
  8. Review
  9. [The diagnosis and treatment progress of olfaction disorders in chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Examining the Influence of Chemosensation on Laryngeal Health and Disorders.Journal of voice : official journal of the Voice Foundation · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Richard L DotySmell & Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Taste and Smell Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sense of smell is largely taken for granted by laypersons and medical professionals alike. Indeed, its role in determining the flavor of foods and beverages, as well as in warning of, or protecting against, environmental hazards, often goes unrecognized. This is exemplified, in part, by the fact that most patients presenting to medical clinics with "taste" problems are typically subjected to complex brain imaging and gastroenterological tests without the sense of smell even being tested or considered as a basis of the problem. Aside from frank deficiencies in sweet, sour, bitter, salty and savory (umami) sensations, "taste" disorders most commonly reflect inadequate stimulation of the olfactory receptors via the retronasal route; i.e., from volatiles passing to the receptors from the oral cavity through the nasal pharynx. This article describes the two most common procedures for measuring the sense of smell in the clinic and provides examples of the application of these tests to diseases and other disorders frequently associated with smell loss. Basic issues related to olfactory testing and evaluation are addressed. It is pointed out that smell loss, particularly in later life, can be a harbinger for not only a range of neurodegenerative diseases, but can be a prognostic indicator of early mortality.

Indexed as

AllergyIatrogenesisNasal diseaseOlfactionPolyposisPsychophysicsRhinosinusitisSmell

Identifiers

PMID29204537
PMCPMC5698508
OpenAlexW2181605306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.