Evidence map›Paper›PMID 29204441›Full record

ArticleBioMed research international2017

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine.

Adriana E Bulboacă, Sorana D Bolboacă, Ioana C Stănescu, Carmen A Sfrângeu, Angelo C Bulboacă

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Oxidative Stress and Migraine.Molecular neurobiology · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Role of Neuroinflammation and Blood-Brain Barrier Permutability on Migraine.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Article
  10. The Use of Antioxidants in the Treatment of Migraine.Antioxidants (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Adriana E BulboacăDepartment of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Str., No. 4-6, 400012 Cluj-Napoca, Romania.
Sorana D BolboacăDepartment of Medical Informatics and Biostatistics, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, Romania.ORCID 0000-0002-2342-4311
Ioana C StănescuDepartment of Neurology and Pediatric Neurology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Str., No. 43, 400012 Cluj-Napoca, Romania.
Carmen A SfrângeuDepartment of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Str., No. 4-6, 400012 Cluj-Napoca, Romania.
Angelo C BulboacăDepartment of Neurology and Pediatric Neurology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Str., No. 43, 400012 Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur study aimed to investigate the analgesic and antioxidative stress effects of Curcumin (CC) in experimental migraine induced by Nitroglycerin (NTG) on rats, compared with Indomethacin (ID) and Propranolol (PP) treatments. MATERIAL AND

methodsFive groups of 10 rats treated i.p. were investigated: control group (healthy rats) injected with saline solution (0.9%), NTG-control group injected with NTG (1 mg/100 gbw, bw = body weight), and three groups with pretreatment applied 30 min previous to the formalin test (NTG + CC group: Curcumin (10 mg/100 gbw), NTG + PP group: Propranolol (100

resultsThe smallest values of malondialdehyde (MDA), nitric oxide (NOx), and total oxidative status (TOS) were observed on NTG + CC with significant differences as compared with the control group (

conclusionOur study demonstrates a superior activity of Curcumin not only versus control, but also versus Propranolol and Indomethacin.

Indexed as

AnalgesicsAnimalsAntioxidantsCurcuminHumansIndomethacinMalondialdehydeMigraine DisordersNitric OxideNitroglycerinOxidative StressPain MeasurementPropranololRatsAnalgesicsAntioxidantsCurcuminIndomethacinMalondialdehydeNitric OxideNitroglycerinPropranolol

Identifiers

PMID29204441
PMCPMC5674483
OpenAlexW2766007070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.