Evidence map›Paper›PMID 29204435›Full record

ArticleERJ open research2017

Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β.

Alice C-H Chen, Yang Xi, Melanie Carroll, Helen L Petsky, Samantha J Gardiner, Susan J Pizzutto, Stephanie T Yerkovich, Katherine J Baines, Peter G Gibson, Sandra Hodge and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects ofPathogens (Basel, Switzerland) · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Alice C-H ChenDiamantina Institute, The University of Queensland, Brisbane, Australia.
Yang XiDiamantina Institute, The University of Queensland, Brisbane, Australia.
Melanie CarrollDiamantina Institute, The University of Queensland, Brisbane, Australia.
Helen L PetskyQueensland University of Technology, CCHR, Brisbane, Australia.
Samantha J GardinerQueensland University of Technology, CCHR, Brisbane, Australia.ORCID 0000-0002-6988-2238
Susan J PizzuttoChild Health Division, Menzies School of Health Research, Charles Darwin Hospital, Darwin, Australia.
Stephanie T YerkovichThe Prince Charles Hospital, Brisbane, Australia.ORCID 0000-0003-4163-4782
Katherine J BainesThe University of Newcastle, Newcastle, Australia.
Peter G GibsonThe University of Newcastle, Newcastle, Australia.
Sandra HodgeHanson Institute, Adelaide, Australia.
Ian B MastersRespiratory and Sleep Medicine, Lady Cilento Children's Hospital, Brisbane, Australia.
Helen M BuntainWesley Hospital, Brisbane, Australia.
Anne B ChangQueensland University of Technology, CCHR, Brisbane, Australia.
John W UphamDiamantina Institute, The University of Queensland, Brisbane, Australia.
The University of Queensland · AUQueensland University of Technology · AUUniversity of Newcastle Australia · AUCharles Darwin University · AUChildren's Health Queensland Hospital and Health Service · AUHanson Institute · AUPrince Charles Hospital · AUWesley Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protracted bacterial bronchitis (PBB) in young children is a common cause of prolonged wet cough and may be a precursor to bronchiectasis in some children. Although PBB and bronchiectasis are both characterised by neutrophilic airway inflammation and a prominent interleukin (IL)-1β signature, the contribution of the IL-1β pathway to host defence is not clear. This study aimed to compare systemic immune responses against common pathogens in children with PBB, bronchiectasis and control children and to determine the importance of the IL-1β pathway. Non-typeable

Identifiers

PMID29204435
PMCPMC5703357
OpenAlexW2761242428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.