Evidence map›Paper›PMID 29204428›Full record

ArticleWorld journal of clinical cases2017

Case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway.

Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yasuko Fujita, Mitsumasa Osakabe, Keisuke Koeda, Takashi Kosaka, Shunichi Yanai, Kazuyuki Ishida, Akira Sasaki and 2 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Noriyuki UesugiDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Ryo SugimotoDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Makoto EizukaDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Yasuko FujitaDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Mitsumasa OsakabeDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Keisuke KoedaDepartment of Surgery, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Takashi KosakaDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Shunichi YanaiDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Kazuyuki IshidaDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Akira SasakiDepartment of Surgery, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Tamotsu SugaiDepartment of Diagnostic Molecular Pathology, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Iwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we report a case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway. A 57-year-old Japanese woman presented with epigastric tenderness, and distal gastrectomy was performed. In the surgical specimen, histologically, the tumor tissue was composed of three subtypes of tumor components showing different histological architecture and cellular atypia, diagnosed as neuroendocrine tumor (NET) G2, NET G3, and neuroendocrine carcinoma (NEC) components. Immunohistochemically, the Ki-67-positive rates of NET G2, NET G3, and NEC components were 6.5%, 99.5% and 88.1%, respectively. Although allelic imbalance (AI) on chromosomes 1p, 3p, 8q, TP53, 18q and 22q was commonly found in all components, AI of 4p was found in NET G3 and NEC components (but not in the NET G2 component). In contrast, AIs of 5q and 9p were found in only the NEC component. Thus, we showed the progression from NET G2 to NEC, via NET G3, within the same tumor.

Indexed as

Neuroendocrine carcinomaNeuroendocrine tumor G2Neuroendocrine tumor G3Stomach

Identifiers

PMID29204428
PMCPMC5700389
OpenAlexW2769579800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.