Evidence map›Paper›PMID 29204368›Full record

ArticleJournal of clinical & translational endocrinology2017

Beneficial effects of oral pure caffeine on oxidative stress.

Daniela Metro, Valeria Cernaro, Domenico Santoro, Mattia Papa, Michele Buemi, Salvatore Benvenga, Luigi Manasseri

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical & translational endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Toxicity of the Covalent Organic Framework Material TpPa to Zebrafish.Animals : an open access journal from MDPI · 2026
    Article
  6. Coffee as a Source of Antioxidants and an Elixir of Youth.Antioxidants (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Caffeine Protects Against Retinal Inflammation.Frontiers in pharmacology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniela MetroDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, University Hospital Policlinico G. Martino, Padiglione G, Messina, Italy.
Valeria CernaroDepartment of Clinical and Experimental Medicine, University of Messina, University Hospital Policlinico G. Martino Padiglione C, Via Consolare Valeria, 98100 Messina, Italy.
Domenico SantoroDepartment of Clinical and Experimental Medicine, University of Messina, University Hospital Policlinico G. Martino Padiglione C, Via Consolare Valeria, 98100 Messina, Italy.
Mattia PapaDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, University Hospital Policlinico G. Martino, Padiglione G, Messina, Italy.
Michele BuemiDepartment of Clinical and Experimental Medicine, University of Messina, University Hospital Policlinico G. Martino Padiglione C, Via Consolare Valeria, 98100 Messina, Italy.
Salvatore BenvengaDepartment of Clinical and Experimental Medicine, University of Messina, Italy.
Luigi ManasseriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, University Hospital Policlinico G. Martino, Padiglione G, Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances) is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols and melanoidins. Very few studies were conducted on the amelioration of classic blood markers of oxidative stress induced after a few days of caffeine administration, but results vary. To assess whether caffeine

Indexed as

CaffeineCoffeeGluthathioneLipid peroxidationMalondialdehydeOxidative stress

Identifiers

PMID29204368
PMCPMC5691215
OpenAlexW2761976702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.