Evidence map›Paper›PMID 29204342›Full record

ArticleNeuroImage. Clinical2018

Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players.

Nico Sollmann, Paul S Echlin, Vivian Schultz, Petra V Viher, Amanda E Lyall, Yorghos Tripodis, David Kaufmann, Elisabeth Hartl, Philipp Kinzel, Lorie A Forwell and 8 more

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In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Observational
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  18. Sex and Gender Science: The World Writes on the Body.Current topics in behavioral neurosciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nico SollmannPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. Electronic address: Nico.Sollmann@tum.de.
Paul S EchlinElliott Sports Medicine Clinic, Burlington, ON, Canada. Electronic address: Psechlin@gmail.com.
Vivian SchultzPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany. Electronic address: VivianSchultz@gmx.de.
Petra V ViherPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Translational Research Center, University Hospital of Psychiatry, Bern, Switzerland. Electronic address: Petra.Viher@puk.unibe.ch.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Alyall@bwh.harvard.edu.
Yorghos TripodisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA. Electronic address: Yorghos@bu.edu.
David KaufmannPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany; Department of Radiology, Charité Universitätsmedizin, Berlin, Germany. Electronic address: David.Kaufmann@charite.de.
Elisabeth HartlPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Epilepsy Center, Ludwig-Maximilians-Universität, Munich, Germany. Electronic address: Elisabeth.Hartl@med.uni-muenchen.de.
Philipp KinzelPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany. Electronic address: Pkinzel@bwh.harvard.edu.
Lorie A Forwell3M Centre, The University of Western Ontario, London, ON, Canada. Electronic address: Lforwell@uwo.ca.
Andrew M JohnsonSchool of Health Studies, The University of Western Ontario, London, ON, Canada. Electronic address: Ajohnson@uwo.ca.
Elaine N SkopeljaRuth Lilly Medical Library, Indiana University, Indianapolis, IN, USA. Electronic address: Eskopelj@iu.edu.
Christian LepagePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; School of Psychology, University of Ottawa, Ottawa, ON, Canada. Electronic address: Clepage@uottawa.ca.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Sylvain@bwh.harvard.edu.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Ofer@bwh.harvard.edu.
Alexander P LinPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Aplin@bwh.harvard.edu.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, USA. Electronic address: Shenton@bwh.harvard.edu.
Inga K KoertePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Ikoerte@bwh.harvard.edu.

Funding

Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
Sex Differences in Brain Structure and Function After Sports-Related ConcussionR01NS100952 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KOERTE, INGA KATHARINA · 2017 to 2022
$2.9M
CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSDR01HD090641 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN · 2016 to 2018
$810k
Development of MR Biomarkers of Brain Injury in Acute and Chronic mTBII01RX000928 · VA · VA BOSTON HEALTH CARE SYSTEM · PI SHENTON, MARTHA E. · 2015 to 2017
–
NICHD NIH HHS R01 HD090641NINDS NIH HHS R01 NS100952NINDS NIH HHS U01 NS093334RRD VA I01 RX000928
6 · The paper itself

Abstract

objectiveRepetitive subconcussive head impacts (RSHI) may lead to structural, functional, and metabolic alterations of the brain. While differences between males and females have already been suggested following a concussion, whether there are sex differences following exposure to RSHI remains unknown. The aim of this study was to identify and to characterize sex differences following exposure to RSHI.

methodsTwenty-five collegiate ice hockey players (14 males and 11 females, 20.6 ± 2.0 years), all part of the Hockey Concussion Education Project (HCEP), underwent diffusion-weighted magnetic resonance imaging (dMRI) before and after the Canadian Interuniversity Sports (CIS) ice hockey season 2011-2012 and did not experience a concussion during the season. Whole-brain tract-based spatial statistics (TBSS) were used to compare pre- and postseason imaging in both sexes for fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Pre- and postseason neurocognitive performance were assessed by the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT).

resultsSignificant differences between the sexes were primarily located within the superior longitudinal fasciculus (SLF), the internal capsule (IC), and the corona radiata (CR) of the right hemisphere (RH). In significant voxel clusters (p < 0.05), decreases in FA (absolute difference pre- vs. postseason: 0.0268) and increases in MD (0.0002), AD (0.00008), and RD (0.00005) were observed in females whereas males showed no significant changes. There was no significant correlation between the change in diffusion scalar measures over the course of the season and neurocognitive performance as evidenced from postseason ImPACT scores.

conclusionsThe results of this study suggest sex differences in structural alterations following exposure to RSHI. Future studies need to investigate further the underlying mechanisms and association with exposure and clinical outcomes.

Indexed as

Sex CharacteristicsBrain ConcussionDiffusion Tensor ImagingFemaleHockeyHumansImage Interpretation, Computer-AssistedMaleWhite MatterYoung AdultAD, axial diffusivityCIS, Canadian Interuniversity SportsCR, corona radiataDiffusion tensor imagingdMRI, diffusion magnetic resonance imagingEC, external capsuleFA, fractional anisotropyHCEP, Hockey Concussion Education ProjectIce hockeyIC, internal capsuleImPACT, Immediate Post-Concussion Assessment and Cognitive TestLH, left hemisphereMD, mean diffusivityMRI, magnetic resonance imagingNCAA, National Collegiate Athletic AssociationRD, radial diffusivityRepetitive subconcussive head impactsRH, right hemisphereRSHI, repetitive subconcussive head impactsrs, Spearman's rank correlation coefficientSD, standard deviationSex differenceSLF, superior longitudinal fasciculusTBI, traumatic brain injuryTBSS, tract-based spatial statisticsTraumatic brain injuryWhite matterWM, white matter

Identifiers

PMID29204342
PMCPMC5709295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.