ReviewTremor and other hyperkinetic movements (New York, N.Y.)2017
Pathogenesis of Primary Orthostatic Tremor: Current Concepts and Controversies.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Systematic review of pharmacological treatment options for orthostatic tremor in prospective patient cohorts and randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Slow Orthostatic Tremor: Review of the Current Evidence.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Differential diagnosis of orthostatic dizziness with persistent postural-perceptual dizziness and its underlying mechanisms.Frontiers in neurology · 2025Review
- Orthostatic tremor after knee contusion without head trauma: A rare case report.Turkish journal of physical medicine and rehabilitation · 2023Article
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- Ataxia Prevalence in Primary Orthostatic Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Remarkable improvement of primary orthostatic tremor using perampanel.Neurological research and practice · 2020Article
- A data mining approach for classification of orthostatic and essential tremor based on MRI-derived brain volume and cortical thickness.Annals of clinical and translational neurology · 2019Article
- Diffusion tensor imaging in orthostatic tremor: a tract-based spatial statistics study.Annals of clinical and translational neurology · 2019Article
- Revisiting the Clinical Phenomenology of "Cerebellar Tremor": Beyond the Intention Tremor.Cerebellum (London, England) · 2019Review
- The Top 50 Most-Cited Articles in Orthostatic Tremor: A Bibliometric Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Review
- Fast Orthostatic Tremor in Parkinson's Disease: Case Report and Comprehensive Review of Literature.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Review
- Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Background: Orthostatic tremor (OT), a rare and complex movement disorder, is characterized by rapid tremor of both legs and the trunk while standing. These disappear while the patient is either lying down or walking. OT may be idiopathic/primary or it may coexist with several neurological conditions (secondary OT/OT plus). Primary OT remains an enigmatic movement disorder and its pathogenesis and neural correlates are not fully understood. Methods: A PubMed search was conducted in July 2017 to identify articles for this review. Results: Structural and functional neuroimaging studies of OT suggest possible alterations in the cerebello-thalamo-cortical network. As with essential tremor, the presence of a central oscillator has been postulated for OT; however, the location of the oscillator within the tremor network remains elusive. Studies have speculated a possible dopaminergic deficit in the pathogenesis of primary OT; however, the evidence in favor of this concept is not particularly robust. There is also limited evidence favoring the concept that primary OT is a neurodegenerative disorder, as a magnetic resonance spectroscopic imaging study revealed significant reduction in cerebral and cerebellar N-acetyl aspartate (NAA) levels, a marker of neuronal compromise or loss. Discussion: Based on the above, it is clear that the pathogenesis of primary OT still remains unclear. However, the available evidence most strongly favors the existence of a central oscillatory network, and involvement of the cerebellum and its connections.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.