ReviewTremor and other hyperkinetic movements (New York, N.Y.)2017
Insights into Pathophysiology from Medication-induced Tremor.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06488651 (Trajectory of Immunosuppression-Caused Tremor In Kidney and Lung Transplant Recipients), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trajectory of Immunosuppression-Caused Tremor In Kidney and Lung Transplant Recipients
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human.Psychopharmacology · 2026Trial
- Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2023Trial
- Smartphone-measured tremor and tacrolimus trough levels in kidney transplant recipients: an exploratory prospective study.Frontiers in transplantation · 2026Article
- Review
- Tremor Induced by Cyclosporine, Tacrolimus, Sirolimus, or Everolimus: A Review of the Literature.Drugs in R&D · 2023Review
- MR-guided focused ultrasound thalamotomy for lithium-induced tremor: a case report and literature review.Frontiers in neurology · 2023Article
- Phenomenology and Physiology of Tacrolimus Induced Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Article
- Medical and Surgical Treatment for Medication-Induced Tremor: Case Report and Systematic Review.Movement disorders clinical practice · 2022Review
- Differentiating tardive dyskinesia: a video-based review of antipsychotic-induced movement disorders in clinical practice.CNS spectrums · 2022Review
- Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor.Cerebellum (London, England) · 2021Article
- Spectral Analysis of Lithium Tremor.Noro psikiyatri arsivi · 2021Article
- Quantifying and Categorizing ADRs in Psychiatric Residential Long-Stay Patients Utilizing UKU-SERS Scale.Indian journal of psychological medicine · 2021Article
- Reply - Clinical Spectrum of Drug-Induced Movement Disorders: A Study of 97 Patients.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Clinical Spectrum of Drug-Induced Movement Disorders: A Study of 97 Patients.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Greater Postural Sway and Tremor during Balance Tasks in Patients with Plantar Fasciitis Compared to Age-Matched Controls.Healthcare (Basel, Switzerland) · 2020Article
- Article
- Current Opinions and Consensus for Studying Tremor in Animal Models.Cerebellum (London, England) · 2019Review
- Movement disorders in emergency settings: a prospective study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Medication-induced tremor (MIT) is common in clinical practice and there are many medications/drugs that can cause or exacerbate tremors. MIT typically occurs by enhancement of physiological tremor (EPT), but not all drugs cause tremor in this way. In this manuscript, we review how some common examples of MIT have informed us about the pathophysiology of tremor. Methods: We performed a PubMed literature search for published articles dealing with MIT and attempted to identify articles that especially dealt with the medication's mechanism of inducing tremor. Results: There is a paucity of literature that deals with the mechanisms of MIT, with most manuscripts only describing the frequency and clinical settings where MIT is observed. That being said, MIT emanates from multiple mechanisms depending on the drug and it often takes an individualized approach to manage MIT in a given patient. Discussion: MIT has provided some insight into the mechanisms of tremors we see in clinical practice. The exact mechanism of MIT is unknown for most medications that cause tremor, but it is assumed that in most cases physiological tremor is influenced by these medications. Some medications (epinephrine) that cause EPT likely lead to tremor by peripheral mechanisms in the muscle (β-adrenergic agonists), but others may influence the central component (amitriptyline). Other drugs can cause tremor, presumably by blockade of dopamine receptors in the basal ganglia (dopamine-blocking agents), by secondary effects such as causing hyperthyroidism (amiodarone), or by other mechanisms. We will attempt to discuss what is known and unknown about the pathophysiology of the most common MITs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.