ArticleNature biomedical engineering2017
Laser-emission imaging of nuclear biomarkers for high-contrast cancer screening and immunodiagnosis.
Article in Nature biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 119 citations in OpenAlex.
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- Properties and Applications of Random Lasers as Emerging Light Sources and Optical Sensors: A Review.Sensors (Basel, Switzerland) · 2022Review
- Virtual histological staining of label-free total absorption photoacoustic remote sensing (TA-PARS).Scientific reports · 2022Article
- Monitoring Various Bioactivities at the Molecular, Cellular, Tissue, and Organism Levels via Biological Lasers.Sensors (Basel, Switzerland) · 2022Review
- Electrochemical biosensor for nucleic acid amplification-free and sensitive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA via CRISPR/Cas13a trans-cleavage reaction.Biosensors & bioelectronics · 2022Article
- Paradigm shift in future biophotonics for imaging and therapy: Miniature living lasers to cellular scale optoelectronics.Theranostics · 2022Review
- Cellular Features Revealed by Transverse Laser Modes in Frequency Domain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase.ACS photonics · 2021Article
- Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021Review
- Topological Encoded Vector Beams for Monitoring Amyloid-Lipid Interactions in Microcavity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Hairpin-Spacer crRNA-Enhanced CRISPR/Cas13a System Promotes the Specificity of Single Nucleotide Polymorphism (SNP) Identification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- CRISPR/Cas13a Powered Portable Electrochemiluminescence Chip for Ultrasensitive and Specific MiRNA Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Enhanced Biophotocurrent Generation in Living Photosynthetic Optical Resonator.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Detection of nuclear biomarkers such as nucleic acids and nuclear proteins is critical for early-stage cancer diagnosis and prognosis. Conventional methods relying on morphological assessment of cell nuclei in histopathology slides may be subjective, whereas colorimetric immunohistochemical and fluorescence-based imaging are limited by strong light absorption, broad-emission bands and low contrast. Here, we describe the development and use of a scanning laser-emission-based microscope that maps lasing emissions from nuclear biomarkers in human tissues. 41 tissue samples from 35 patients labelled with site-specific and biomarker-specific antibody-conjugated dyes were sandwiched in a Fabry-Pérot microcavity while an excitation laser beam built a laser-emission image. We observed multiple sub-cellular lasing emissions from cancer cell nuclei, with a threshold of tens of μJ/mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.