Evidence map›Paper›PMID 29204305›Full record

ArticleJournal of drug and alcohol research2017

Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-

Ming Tong, Howard Gonzalez-Navarrete, Tyler Kirchberg, Billy Gotama, Emine B Yalcin, Jared Kay, Suzanne M de la Monte

Open access · greenAbstract read
In one paragraph

Article in Journal of drug and alcohol research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
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  4. Long-Term Excessive Alcohol Consumption Enhances Myelination in the Mouse Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  17. Review
  18. Article
  19. Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ming TongLiver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Howard Gonzalez-NavarreteBrown University, Providence, RI 02912, USA.
Tyler KirchbergBrown University, Providence, RI 02912, USA.
Billy GotamaMolecular Pharmacology and Biotechnology Graduate Program, Brown University, Providence, RI 02912, USA.
Emine B YalcinLiver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Jared KayLiver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Suzanne M de la MonteLiver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Brown University · US

Funding

FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle AssaysR01AA011431 · NIAAA · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI SUZANNE M. DE LA MONTE · 1996 to 2026
$5.4M
Ethanol, IRS-1 Signaling and Neuronal MigrationR37AA011431 · NIAAA · RHODE ISLAND HOSPITAL · PI DE LA MONTE, SUZANNE M. · 2009 to 2018
$3.7M
EFFECTS OF ETHANOL ON INSULIN SIGNALING IN THE BRAINR01AA012908 · NIAAA · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI DE LA MONTE, SUZANNE M. · 2003 to 2013
$3.0M
ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATIONR56AA011431 · NIAAA · RHODE ISLAND HOSPITAL · PI DE LA MONTE, SUZANNE M. · 2008 to 2008
$312k
NIAAA NIH HHS R01 AA011431NIAAA NIH HHS R01 AA012908NIAAA NIH HHS R37 AA011431NIAAA NIH HHS R56 AA011431
6 · The paper itself

Abstract

Alcohol-induced white matter (WM) degeneration is linked to cognitive-motor deficits and impairs insulin/insulin-like growth factor (IGF) and Notch networks regulating oligodendrocyte function. Ethanol downregulates Aspartyl-Asparaginyl-

Indexed as

alcoholaspartyl-asparaginyl-β-hydroxylasehypoxia-inducing factor 1-alphaneurodegenerationNotcholigodendrocyteswhite matter

Identifiers

PMID29204305
PMCPMC5711436
OpenAlexW2748726593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.