Evidence map›Paper›PMID 29204250›Full record

ReviewOxidative medicine and cellular longevity2017

Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry.

Nayansi Jha, Jae Jun Ryu, Eun Ha Choi, Nagendra Kumar Kaushik

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Nayansi JhaDepartment of Oral and Maxillofacial Implantology, Graduate School of Clinical Dentistry, Korea University, Seoul, Republic of Korea.
Jae Jun RyuDepartment of Oral and Maxillofacial Implantology, Graduate School of Clinical Dentistry, Korea University, Seoul, Republic of Korea.
Eun Ha ChoiPlasma Bioscience Research Centre, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea.ORCID 0000-0001-5385-1878
Nagendra Kumar KaushikPlasma Bioscience Research Centre, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea.ORCID 0000-0002-4965-5046
Kwangwoon University · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of reactive oxygen and nitrogen species (RONS) has been found to occur during inflammatory procedures, during cell ischemia, and in various crucial developmental processes such as cell differentiation and along cell signaling pathways. The most common sources of intracellular RONS are the mitochondrial electron transport system, NADH oxidase, and cytochrome P450. In this review, we analyzed the extracellular and intracellular sources of reactive species, their cell signaling pathways, the mechanisms of action, and their positive and negative effects in the dental field. In dentistry, ROS can be found-in lasers, photosensitizers, bleaching agents, cold plasma, and even resin cements, all of which contribute to the generation and prevalence of ROS. Nonthermal plasma has been used as a source of ROS for biomedical applications and has the potential for use with dental stem cells as well. There are different types of dental stem cells, but their therapeutic use remains largely untapped, with the focus currently on only periodontal ligament stem cells. More research is necessary in this area, including studies about ROS mechanisms with dental cells, along with the utilization of reactive species in redox medicine. Such studies will help to provide successful treatment modalities for various diseases.

Indexed as

LasersCytochrome P-450 Enzyme SystemHumansLow-Level Light TherapyNADPH OxidasesOxidative StressPhotosensitizing AgentsPlasma GasesReactive Nitrogen SpeciesReactive Oxygen SpeciesStem CellsTooth DiseasesCytochrome P-450 Enzyme SystemNADPH OxidasesPhotosensitizing AgentsPlasma GasesReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID29204250
PMCPMC5674515
OpenAlexW2766037870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.